Evidence map›Paper›PMID 31153828›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2019

circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer.

Yuting Sang, Bing Chen, Xiaojin Song, Yaming Li, Yiran Liang, Dianwen Han, Ning Zhang, Hanwen Zhang, Ying Liu, Tong Chen and 4 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 247 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
247citing papers in PubMed, 2 pooled it
27.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

247 citing papers in PubMed, 2 syntheses or guidelines pooled it, 510 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Circular RNAs in ferroptosis regulation and tumor progression of gynecological and breast cancers: molecular mechanisms and therapeutic potential.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  5. Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  11. The Interaction ofInternational journal of biological sciences · 2026
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187 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Yuting SangDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Bing ChenPathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Xiaojin SongDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Yaming LiDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Yiran LiangDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Dianwen HanDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Ning ZhangDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Hanwen ZhangDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Ying LiuDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Tong ChenDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Chen LiDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Lijuan WangPathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Wenjing ZhaoPathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Qifeng YangDepartment of Breast Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China; Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address: qifengy_sdu@163.com.
Qilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tamoxifen is the most commonly used endocrine therapy for patients with hormone receptor (HR)-positive breast cancer. Despite its initial therapeutic efficacy, many patients eventually develop drug resistance, which remains a serious clinical challenge. To investigate roles of circular RNAs (circRNAs) in tamoxifen resistance, a tamoxifen-resistant MCF-7 cell line was established and screened for its circRNA expression profile by RNA sequencing. hsa_circ_0025202, a circRNA that was significantly downregulated, was selected for further investigation. Using a large cohort of clinical specimens, we found that hsa_circ_0025202 exhibited low expression in cancer tissues and was negatively correlated with lymphatic metastasis and histological grade. Gain- and loss-of-function assays indicated that hsa_circ_0025202 could inhibit cell proliferation, colony formation, and migration and increase cell apoptosis and sensitivity to tamoxifen. Bioinformatics and luciferase reporter assays verified that hsa_circ_0025202 could act as a miRNA sponge for miR-182-5p and further regulate the expression and activity of FOXO3a. Functional studies revealed that tumor inhibition and tamoxifen sensitization effects of hsa_circ_0025202 were achieved via the miR-182-5p/FOXO3a axis. Moreover, in vivo experiments confirmed that hsa_circ_0025202 could suppress tumor growth and enhance tamoxifen efficacy. Taken together, hsa_circ_0025202 served an anti-oncogenic role in HR-positive breast cancer, and it could be exploited as a novel marker for tamoxifen-resistant breast cancer.

Indexed as

Gene Expression Regulation, Neoplastic3' Untranslated RegionsAdultAgedAnimalsApoptosisBiomarkers, TumorBreast NeoplasmsCell Line, TumorCell MovementDisease Models, AnimalDisease ProgressionDrug Resistance, NeoplasmFemaleForkhead Transcription FactorsGene Knockdown Techniques3' Untranslated RegionsBiomarkers, TumorForkhead Transcription FactorsFOXP3 protein, humanMicroRNAsMirn182 microRNA, humanRNA, CircularTamoxifenbreast cancerceRNAcircRNAhsa_circ_0025202tamoxifen resistance

Identifiers

PMID31153828
PMCPMC6731174
OpenAlexW2945838677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.