ArticleNeuron2019
Temporally and Spatially Distinct Thirst Satiation Signals.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Review
- A novel interoceptive subfornical organ to infralimbic cortex mechanism relays airway inflammation effects on fear extinction.Journal of neuroinflammation · 2026Article
- A novel interoceptive subfornical organ to infralimbic cortex mechanism relays airway inflammation effects on fear extinction.Research square · 2026Article
- A bottom-up septal inhibitory circuit mediates anticipatory control of drinking.Nature neuroscience · 2025Article
- Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance.NPJ science of food · 2025Article
- Neurochemical Aspects of the Role of Thirst in Body Fluid Homeostasis and Their Significance in Health and Disease: A Literature Review.International journal of molecular sciences · 2025Review
- What's the occasion? Phasic dopamine signaling and interoception.Current opinion in neurobiology · 2025Review
- A Poly(methacrolein-Nanomaterials (Basel, Switzerland) · 2025Article
- Body fluid regulation.Current opinion in neurobiology · 2025Review
- Vagal Sensory Gut-Brain Pathways That Control Eating-Satiety and Beyond.Comprehensive physiology · 2025Review
- The neurobiology of thirst and salt appetite.Neuron · 2024Review
- Dysregulation of the fluid homeostasis system by aging.bioRxiv : the preprint server for biology · 2024Article
- The cerebellum modulates thirst.Nature neuroscience · 2024Article
- The influence of olfactory experience on the birthrates of olfactory sensory neurons with specific odorant receptor identities.Genesis (New York, N.Y. : 2000) · 2024Review
- Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need.Science (New York, N.Y.) · 2024Article
- Multicore fiber optic imaging reveals that astrocyte calcium activity in the mouse cerebral cortex is modulated by internal motivational state.Nature communications · 2024Article
- Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice.Nature communications · 2024Article
- Article
- Feeding signals inhibit fluid-satiation signals in the mouse lateral parabrachial nucleus to increase intake of highly palatable, caloric solutions.Journal of neurochemistry · 2023Article
- Article
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Authors and funding
8 authors.
Funding
Abstract
For thirsty animals, fluid intake provides both satiation and pleasure of drinking. How the brain processes these factors is currently unknown. Here, we identified neural circuits underlying thirst satiation and examined their contribution to reward signals. We show that thirst-driving neurons receive temporally distinct satiation signals by liquid-gulping-induced oropharyngeal stimuli and gut osmolality sensing. We demonstrate that individual thirst satiation signals are mediated by anatomically distinct inhibitory neural circuits in the lamina terminalis. Moreover, we used an ultrafast dopamine (DA) sensor to examine whether thirst satiation itself stimulates the reward-related circuits. Interestingly, spontaneous drinking behavior but not thirst drive reduction triggered DA release. Importantly, chemogenetic stimulation of thirst satiation neurons did not activate DA neurons under water-restricted conditions. Together, this study dissected the thirst satiation circuit, the activity of which is functionally separable from reward-related brain activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.