Evidence map›Paper›PMID 31153628›Full record

Trial reportBritish journal of anaesthesia2019

Transmuscular quadratus lumborum block for percutaneous nephrolithotomy reduces opioid consumption and speeds ambulation and discharge from hospital: a single centre randomised controlled trial.

Mette Dam, Christian K Hansen, Troels D Poulsen, Nessn H Azawi, Morné Wolmarans, Vincent Chan, Gunnar H Laier, Thomas F Bendtsen, Jens Børglum

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02818140 phase4completednot on this map

Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Percutaneous Nephrolithotomy

TypeinterventionalSponsorZealand University HospitalRan2016 to 2018Enrolled60ConditionsKidney StoneArmsRopivacaine TQL block, Saline TQL block, Ropivacaine, Saline, Ultrasound
NCT04951752 unknown statusnot on this mapstarted 2021, after this paper: background citation

Effect of the Transmuscular Quadratus Lumborum Block on Duration of Stay in Recovery: a Single-centre, Retrospective, Observational Study Based on Five Selected Randomised Controlled Trials

TypeobservationalSponsorZealand University HospitalRan2021 to 2021Enrolled307ConditionsAnesthesia, LocalArmsRopivacaine injection
NCT05822492 completednot on this mapstarted 2023, after this paper: background citation

Comparison of the Effects of Anterior Quadratus Lumborum Block and Erector Spina Plane Block on Postoperative Acute Pain in Percutaneous Nephrolithotomy Surgery

TypeobservationalSponsorOndokuz Mayıs UniversityRan2023 to 2023Enrolled90ConditionsAnesthesia, Analgesia, Patient Controlled Analgesia, Quadratus Lumborum BlockArmsGroup QLB3, Group ESPB, Group Control
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mette DamDepartment of Anaesthesiology and Intensive Care Medicine, Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark.
Christian K HansenDepartment of Anaesthesiology and Intensive Care Medicine, Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark.
Troels D PoulsenDepartment of Anaesthesiology and Intensive Care Medicine, Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark.
Nessn H AzawiDepartment of Urology, Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark.
Morné WolmaransDepartment of Anaesthesiology, Norfolk and Norwich University Hospitals, Norfolk, UK.
Vincent ChanDepartment of Anaesthesiology, Western Hospital, University of Toronto, Toronto, ON, Canada.
Gunnar H LaierRegion Zealand, Production, Research & Innovation, Sorø, Denmark.
Thomas F BendtsenDepartment of Anaesthesiology, Aarhus University Hospital, Aarhus, Denmark.
Jens BørglumDepartment of Anaesthesiology and Intensive Care Medicine, Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address: jens.borglum@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPercutaneous nephrolithotomy (PNL) is associated with severe postoperative pain. The current study aimed to investigate the analgesic efficacy of transmuscular quadratus lumborum (TQL) block for patients undergoing PNL surgery.

methodsSixty patients were enrolled in this single centre study. The multimodal analgesic regime consisted of oral paracetamol 1 g and i.v. dexamethasone 4 mg before surgery and i.v. sufentanil 0.25 μg kg

resultsMorphine consumption was lower in the intervention group at 6 h after surgery (7.2 [8.7] vs 90.6 [69.9] mg OME, P<0.001) and at 24 h (54.0 [36.7] vs 126.2 [85.5] mg OME, P<0.001). Time to first opioid use was prolonged in the intervention group (678 [285-1020] vs 36 [19-55] min, P<0.0001). Both the time to ambulation (302 [238-475] vs 595 [345-925] min, P<0.004) and length of stay (2.0 [0.8] vs 3.0 [1.2] days, P≤0.001) were shorter in the intervention group.

conclusionsThis is the first blinded, RCT that confirms that unilateral TQL block reduces postoperative opioid consumption and hospital length of stay. Further study is required for confirmation and dose optimisation. CLINICAL

trial registrationNCT02818140.

Indexed as

Nephrolithotomy, PercutaneousAbdominal MusclesAdultAgedAged, 80 and overAnalgesics, OpioidDouble-Blind MethodEarly AmbulationFemaleHumansMaleMiddle AgedNerve BlockPatient DischargePostoperative PainProspective StudiesAnalgesics, Opioidlength of hospital staylocal anaestheticmultimodal analgesianerve blockpostoperative painquadratus lumborum blockultrasonography

Identifiers

PMID31153628
PMCPMC6676058

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.