Evidence map›Paper›PMID 31153360›Full record

Trial reportBMC anesthesiology2019

Optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough suppression: a prospective randomized controlled trial.

Wei Zhou, Dongsheng Zhang, Shunping Tian, Yang Yang, Zhi Xing, Rongrong Ma, Tianqi Zhou, Tianxiu Bao, Jianhong Sun, Zhuan Zhang

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03126422 (Effects of Different Doses of Dexmedetomidine on Fentanyl-induced Cough), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03126422 phase1unknown statusnot on this map

Effects of Different Doses of Dexmedetomidine on Fentanyl-induced Cough

TypeinterventionalSponsorYangzhou UniversityRan2017 to 2017Enrolled240ConditionsFentanyl-induced CoughArmsDexmedetomidine
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Wei ZhouSchool of Medicine, Yangzhou University, Yangzhou, 225009, China.
Dongsheng ZhangDepartment of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, 225012, China.
Shunping TianSchool of Medicine, Yangzhou University, Yangzhou, 225009, China.
Yang YangDepartment of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, 225012, China.
Zhi XingDepartment of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, 225012, China.
Rongrong MaDepartment of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, 225012, China.
Tianqi ZhouPreventive Health Care Office, The Affiliated Hospital of Yangzhou University, Yangzhou, 225012, China.
Tianxiu BaoDepartment of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, 225012, China.
Jianhong SunDepartment of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, 225012, China.
Zhuan ZhangDepartment of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, 225012, China. zhangzhuancg@163.com.ORCID 0000-0002-7295-9013
Yangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the optimal dose of pretreated-dexmedetomidine in fentanyl-induced cough (FIC) suppression.

methodsPatients of 180 undergoing elective surgery with general anesthesia, aged 18-65 years, BMI 18.5-30 kg/m

resultsTotally 168 patients completed the study. The incidences of cough were 52.4, 42.9, 11.9, and 14.3% in groups 1, 2, 3, and 4, respectively, with no significant differences between groups 1 and 2 (P > 0.05) and between groups 3 and 4 (P > 0.05). The incidence and severity of cough in groups 3 and 4 were significantly lower than those in groups 1 and 2 (P < 0.05). Compared to T0, HR at T2 (P < 0.05), T3 (P < 0.01), and T4 (P < 0.01) decreased significantly and MAP at T4 decreased significantly (P < 0.05) in group 4. Bradycardia occurred in 1 case and respiratory depression occurred in 1 case in group 4. Compared to group 1, the onset time of cough in the other 3 groups were delayed significantly (P < 0.05).

conclusionPretreated dexmedetomidine 0.6 mcg/kg blous intravenous infusion over 10 mins could reduce FIC effectively without side effects.

trial registrationThis study was registered in ClinicalTrials.gov (NCT03126422), April 13, 2017.

Indexed as

AdultAnalgesics, OpioidAnesthesia, GeneralCoughDexmedetomidineDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleFemaleFentanylFollow-Up StudiesHumansHypnotics and SedativesMaleMiddle AgedProspective StudiesAnalgesics, OpioidDexmedetomidineFentanylHypnotics and SedativesCoughDexmedetomidineFentanyl

Identifiers

PMID31153360
PMCPMC6545214
OpenAlexW2947191407

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.