Trial reportBMC anesthesiology2019
A comparison of effects of scalp nerve block and local anesthetic infiltration on inflammatory response, hemodynamic response, and postoperative pain in patients undergoing craniotomy for cerebral aneurysms: a randomized controlled trial.
Trial report in BMC anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comparison Between Scalp Nerve Block and Scalp Infiltration on the Circulatory and Stress Response for Aneurysm Clipping Using an Enhanced Recovery After Surgery Programme
Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy
Investigation of the Effects of Preoperative Ultrasound-Guided Scalp Block on Perioperative Opioid Consumption, Hemodynamic Stability, and Inflammatory Response in Patients Undergoing Craniotomy With a Skull Pin Head Holder
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Level of evidence of enhanced recovery after surgery (ERAS) strategies for elective craniotomy: An updated systematic review.Neurosurgical review · 2026Pooled it
- Effect of the enhanced recovery after surgery protocol in patients undergoing elective craniotomies: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Prevention of Post-Operative Pain after Elective Brain Surgery: A Meta-Analysis of Randomized Controlled Trials.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Safety and efficacy of dexmedetomidine in combination with ropivacaine for lumbar paravertebral block in posterior lumbar surgery: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Preemptive analgesia with parecoxib sodium alleviates short-term pain after endoscopic submucosal dissection for early esophageal cancer and precancerous lesions: a single-center, double-arm, and randomized controlled study.Frontiers in oncology · 2026Trial
- Efficacy of Preemptive Topical Lidocaine 5% Plaster in the Prevention of Post-Craniotomy Pain, a Randomized Clinical Trial.Journal of pain research · 2024Trial
- Ultrasound-guided scalp nerve block in anesthesia of children receiving cranial suture reconstruction.BMC anesthesiology · 2023Trial
- Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial.Croatian medical journal · 2021Trial
- "Enhanced recovery after surgery - ERAS in elective craniotomies-a non-randomized controlled trial".BMC neurology · 2021Trial
- A randomized controlled trial evaluating the hemodynamic impact of ultrasound-guided great auricular nerve block in middle ear microsurgery.BMC anesthesiology · 2020Trial
- Trial
- Evaluation of the Effect of Scalp Nerve Block on Bispectral Index Values During Skull Pinning; Prospective Observational Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Regional scalp block for post-craniotomy pain management in children: a scoping review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Evaluation of Liposomal Bupivacaine Use in Elective Cerebral Aneurysm Surgery.Neurosurgery practice · 2025Article
- Effect of ultrasound-guided scalp nerve block on hemodynamics and postoperative agitation in hypertensive cerebral hemorrhage craniotomy patients: a prospective randomized controlled study.Frontiers in neurology · 2025Article
- Article
- Nerve Blocks for Craniotomy.Current pain and headache reports · 2024Review
- Article
- Cost-effectiveness and efficacy of scalp block for elective supratentorial craniotomy in resource-limited settings: A randomized controlled trial.Surgical neurology international · 2024Article
- Effects of Scalp Nerve Block on the Quality of Recovery after Minicraniotomy for Clipping of Unruptured Intracranial Aneurysms : A Randomized Controlled Trial.Journal of Korean Neurosurgical Society · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to compare the effects of scalp nerve block (SNB) and local anesthetic infiltration (LA) with 0.75% ropivacaine on postoperative inflammatory response, intraoperative hemodynamic response, and postoperative pain control in patients undergoing craniotomy.
methodsFifty-seven patients were admitted for elective craniotomy for surgical clipping of a cerebral aneurysm. They were randomly divided into three groups: Group S (SNB with 15 mL of 0.75% ropivacaine), group I (LA with 15 mL of 0.75% ropivacaine) and group C (that only received routine intravenous analgesia). Pro-inflammatory cytokine levels in plasma for 72 h postoperatively, hemodynamic response to skin incision, and postoperative pain intensity were measured.
resultsThe SNB with 0.75% ropivacaine not only decreased IL-6 levels in plasma 6 h after craniotomy but also decreased plasma CRP levels and increased plasma IL-10 levels 12 and 24 h after surgery compared to LA and routine analgesia. There were significant increases in mean arterial pressure 2 and 5 mins after the incision and during dura opening in Groups I and C compared with Group S. Group S had lower postoperative pain intensity, longer duration before the first dose of oxycodone, less consumption of oxycodone and lower incidence of PONV through 48 h postoperatively than Groups I and C.
conclusionPreoperative SNB attenuated inflammatory response to craniotomy for cerebral aneurysms, blunted the hemodynamic response to scalp incision, and controlled postoperative pain better than LA or routine analgesia.
trial registrationClinicaltrials.gov NCT03073889 (PI:Xi Yang; date of registration:08/03/2017).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.