ArticleThe Review of scientific instruments2019
High-density diffuse optical tomography for imaging human brain function.
Article in The Review of scientific instruments, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
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Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Stochastic numerical head phantoms to enable virtual imaging studies of transcranial photoacoustic computed tomography.Photoacoustics · 2026Article
- Treatment-related Cognitive Impairment, Neurovascular Coupling, and Iron Levels in Women with Ovarian Cancer.medRxiv : the preprint server for health sciences · 2026Article
- Transcutaneous auricular vagus nerve stimulation during a 3-back task: a high-density functional near-infrared spectroscopy study.Experimental brain research · 2026Article
- Disrupted functional connectivity during stroke recovery revealed via bedside optical neuroimaging.Neurophotonics · 2026Article
- Extending effective multiplicity for independent designs in multichannel fNIRS studies.Neurophotonics · 2026Article
- Exploring fNIRS-guided neurofeedback for supplementary motor area training in Parkinson's disease and healthy older adults.NPJ Parkinson's disease · 2026Article
- Latent diffusion-based image reconstruction for near-infrared spectral tomography.Biomedical optics express · 2026Article
- Surface-based image reconstruction optimization for high-density functional near-infrared spectroscopy.Neurophotonics · 2026Article
- LoGoReg-Net: local-global feature aggregation regularized unrolling network for functional brain imaging via high-density DOT.Biomedical optics express · 2026Article
- CoMind R1: a time-resolved interferometric optical neuromonitoring system for pulsatile cerebral blood flow measurement at late times-of-flight.Neurophotonics · 2026Article
- Inferring neural sources from electroencephalography: foundations and frontiers.Journal of neural engineering · 2026Review
- Mapping functional connectivity in the pigeon brain with wide-field optical imaging.Neurophotonics · 2026Article
- Visual Semantic Encoding and Identification of Naturalistic Movies via High-Density Diffuse Optical Tomography.bioRxiv : the preprint server for biology · 2025Article
- NIRFASTerFF: an accessible, cross-platform Python package for fast photon modeling.Journal of biomedical optics · 2025Article
- Anisotropic light propagation in human brain white matter.Neurophotonics · 2025Article
- Automatic photoacoustic monitoring of perinatal brain hypoxia with superior sagittal sinus detection.Journal of biomedical optics · 2025Article
- High-density multidistance fNIRS enhances detection of brain activity during a word-color Stroop task.Neurophotonics · 2025Article
- Finite Element Modeling of Abdominal Near-Infrared Spectroscopy for Infant Splanchnic Oximetry.International journal for numerical methods in biomedical engineering · 2025Article
- NIRSTORM: a Brainstorm extension dedicated to functional near-infrared spectroscopy data analysis, advanced 3D reconstructions, and optimal probe design.Neurophotonics · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
This review describes the unique opportunities and challenges for noninvasive optical mapping of human brain function. Diffuse optical methods offer safe, portable, and radiation free alternatives to traditional technologies like positron emission tomography or functional magnetic resonance imaging (fMRI). Recent developments in high-density diffuse optical tomography (HD-DOT) have demonstrated capabilities for mapping human cortical brain function over an extended field of view with image quality approaching that of fMRI. In this review, we cover fundamental principles of the diffusion of near infrared light in biological tissue. We discuss the challenges involved in the HD-DOT system design and implementation that must be overcome to acquire the signal-to-noise necessary to measure and locate brain function at the depth of the cortex. We discuss strategies for validation of the sensitivity, specificity, and reliability of HD-DOT acquired maps of cortical brain function. We then provide a brief overview of some clinical applications of HD-DOT. Though diffuse optical measurements of neurophysiology have existed for several decades, tremendous opportunity remains to advance optical imaging of brain function to address a crucial niche in basic and clinical neuroscience: that of bedside and minimally constrained high fidelity imaging of brain function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.