Evidence map›Paper›PMID 31153058›Full record

ReviewCurrent opinion in cell biology2019

Flexibility sustains epithelial tissue homeostasis.

Karen Tai, Katie Cockburn, Valentina Greco

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  6. Review
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  9. ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Article
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  16. Article
  17. Tracing the Dynamics of Stem Cell Fate.Cold Spring Harbor perspectives in biology · 2020
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karen TaiDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.
Katie CockburnDepartments of Cell Biology & Dermatology, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: Katherine.cockburn@yale.edu.
Valentina GrecoDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Cell Biology & Dermatology, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: Valentina.greco@yale.edu.

Funding

Live Imaging of Skin RegenerationR01AR063663 · NIAMS · YALE UNIVERSITY · PI Valentina Greco · 2012 to 2026
$7.7M
Understanding Skin Tissue Repair in Live MammalsR01AR072668 · NIAMS · YALE UNIVERSITY · PI Valentina Greco · 2018 to 2026
$6.2M
Normal stem cells and their transition to disease in the skinR01AR067755 · NIAMS · YALE UNIVERSITY · PI GRECO, VALENTINA · 2016 to 2020
$2.2M
CIHRHoward Hughes Medical InstituteNIAMS NIH HHS R01 AR063663NIAMS NIH HHS R01 AR067755NIAMS NIH HHS R01 AR072668
6 · The paper itself

Abstract

Epithelia surround our bodies and line most of our organs. Intrinsic homeostatic mechanisms replenish and repair these tissues in the face of wear and tear, wounds, and even the presence of accumulating mutations. Recent advances in cell biology, genetics, and live-imaging techniques have revealed that epithelial homeostasis represents an intrinsically flexible process at the level of individual epithelial cells. This homeostatic flexibility has important implications for how we think about the more dramatic cell plasticity that is frequently thought to be associated with pathological settings. In this review, we will focus on key emerging mechanisms and processes of epithelial homeostasis and elaborate on the known molecular mechanisms of epithelial cell interactions to illuminate how epithelia are maintained throughout an organism's lifetime.

Indexed as

HomeostasisAnimalsCarcinogenesisEpitheliumHumansMutationWound Healing

Identifiers

PMID31153058
PMCPMC6756930

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.