Evidence map›Paper›PMID 31152821›Full record

ReviewBiochimica et biophysica acta. Reviews on cancer2019

Clinical validity of saliva and novel technology for cancer detection.

Karolina Elżbieta Kaczor-Urbanowicz, Fang Wei, Shannon Liu Rao, Jinseok Kim, Heebum Shin, Jordan Cheng, Michael Tu, David T W Wong, Yong Kim

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta. Reviews on cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. miR-185 in salivary extracellular vesicles for early diagnosis of malignant transformation in oral leukoplakia: a clinical study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. From gut to mouth: salivary signatures of carcinogenic microbiota.Frontiers in cellular and infection microbiology · 2026
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Karolina Elżbieta Kaczor-UrbanowiczCenter for Oral and Head/Neck Oncology Research, School of Dentistry, University of California at Los Angeles, United States of America; UCLA's Section of Orthodontics, UCLA School of Dentistry, University of California at Los Angeles, United States of America.
Fang WeiCenter for Oral and Head/Neck Oncology Research, School of Dentistry, University of California at Los Angeles, United States of America.
Shannon Liu RaoCenter for Oral and Head/Neck Oncology Research, School of Dentistry, University of California at Los Angeles, United States of America.
Jinseok KimCenter for Oral and Head/Neck Oncology Research, School of Dentistry, University of California at Los Angeles, United States of America.
Heebum ShinCenter for Oral and Head/Neck Oncology Research, School of Dentistry, University of California at Los Angeles, United States of America.
Jordan ChengCenter for Oral and Head/Neck Oncology Research, School of Dentistry, University of California at Los Angeles, United States of America.
Michael TuEZLife Bio Inc., 21250 Califa St #101, Woodland Hills, CA 9367, United States of America.
David T W WongCenter for Oral and Head/Neck Oncology Research, School of Dentistry, University of California at Los Angeles, United States of America; UCLA's Jonsson Comprehensive Cancer Center, United States of America. Electronic address: dtww@ucla.edu.
Yong KimCenter for Oral and Head/Neck Oncology Research, School of Dentistry, University of California at Los Angeles, United States of America; UCLA's Jonsson Comprehensive Cancer Center, United States of America. Electronic address: thadyk@ucla.edu.

Funding

Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer DetectionUH3TR000923 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2015 to 2017
$2.7M
Advancing EFIRM-Liquid Biopsy (eLB) to a CLIA-Certified Laboratory Developed Test (eLB-LDT) for Detection of Actionable EGFR Mutations in NSCLC PatientsUH3CA206126 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHIA, DAVID S., SOO HOO, GUY · 2019 to 2021
$1.2M
Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer DetectionUH2TR000923 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2013 to 2014
$996k
NCATS NIH HHS UH2 TR000923NCATS NIH HHS UH3 TR000923NCI NIH HHS UH3 CA206126
6 · The paper itself

Abstract

Cancer, a local disease at an early stage, systemically evolves as it progresses by triggering alterations in surrounding microenvironment, disturbing immune surveillance and further disseminating its molecular contents into circulation. This pathogenic characteristic of cancer makes the use of biofluids such as blood/serum/plasma, urine, tear and cerebrospinal fluids credible surrogates harboring tumor tissue-derived molecular alterations for the detection of cancer. Most importantly, a number of recent reports have credentialed the clinical validity of saliva for the detection of systemic diseases including cancers. In this review, we discussed the validity of saliva as credible biofluid and clinical sample type for the detection of cancers. We have presented the molecular constituents of saliva that could mirror the systemic status of our body and recent findings of salivaomics associated with cancers. Recently, liquid biopsy to detect cancer-derived circulating tumor DNA has emerged as a credible cancer-detection tool with potential benefits in screening, diagnosis and also risk management of cancers. We have further presented the clinical validity of saliva for liquid biopsy of cancers and a new technology platform based on electrochemical detection of cancer-derived ctDNA in saliva with superior sensitivity and point-of-care potential. The clinical utilities of saliva for the detection of cancers have been evidenced, but biological underpinning on the existence of molecular signatures of cancer-origin in saliva, such as via exosomal distribution, should be addressed in detail.

Indexed as

Early Detection of CancerBiomarkers, TumorCirculating Tumor DNAHumansLiquid BiopsyNeoplasmsSalivaTumor MicroenvironmentBiomarkers, TumorCirculating Tumor DNABiomarkerCancer detectionCirculating tumor DNA (ctDNA)Electric Feld Induced Release and Measurement (EFIRM)Liquid biopsySaliva

Identifiers

PMID31152821
PMCPMC6692231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.