Evidence map›Paper›PMID 31152523›Full record

ReviewMicrobiology spectrum2019

The Role of the Type III Secretion System in the Intracellular Lifestyle of Enteric Pathogens.

Marcela De Souza Santos, Kim Orth

Open access · greenAbstract readReview
In one paragraph

Review in Microbiology spectrum, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. mSphere · 2024
    Article
  3. Comprehensive Genomic Analysis of UropathogenicPathogens (Basel, Switzerland) · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Recent Progress inPathogens (Basel, Switzerland) · 2021
    Review
  10. Article
  11. Adaptations ofFrontiers in microbiology · 2021
    Review
  12. Article
  13. Article
  14. The interaction ofMicrobiology (Reading, England) · 2020
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marcela De Souza SantosDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Kim OrthDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
The University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several pathogens have evolved to infect host cells from within, which requires subversion of many host intracellular processes. In the case of Gram-negative pathogenic bacteria, adaptation to an intracellular life cycle relies largely on the activity of type III secretion systems (T3SSs), an apparatus used to deliver effector proteins into the host cell, from where these effectors regulate important cellular functions such as vesicular trafficking, cytoskeleton reorganization, and the innate immune response. Each bacterium is equipped with a unique suite of these T3SS effectors, which aid in the development of an individual intracellular lifestyle for their respective pathogens. Some bacteria adapt to reside and propagate within a customized vacuole, while others establish a replicative niche in the host cytosol. In this article, we review the mechanisms by which T3SS effectors contribute to these different lifestyles. To illustrate the formation of a vacuolar and a cytosolic lifestyle, we discuss the intracellular habitats of the enteric pathogens

Indexed as

CytoplasmCytosolGram-Negative BacteriaHost-Pathogen InteractionsHumansImmunity, InnateProtein TransportSalmonella typhimuriumShigella flexneriType III Secretion SystemsVacuolesVibrio parahaemolyticusType III Secretion Systems

Identifiers

PMID31152523
PMCPMC11026088
OpenAlexW2947797966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.