Evidence map›Paper›PMID 31152482›Full record

ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2019

Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early-onset lone atrial fibrillation.

Mariam B Seifert, Morten S Olesen, Ingrid E Christophersen, Jonas B Nielsen, Jonas Carlson, Fredrik Holmqvist, Arnljot Tveit, Stig Haunsø, Jesper H Svendsen, Pyotr G Platonov

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Discovery ofDiagnostics (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early-onset lone atrial fibrillation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Mariam B SeifertThe Center for Integrative Electrocardiology, Arrhythmia Clinic Skåne University Hospital, Lund University (CIEL), Lund, Sweden.
Morten S OlesenDanish National Research Foundation Center for Cardiac Arrhythmia, Copenhagen, Denmark.
Ingrid E ChristophersenThe Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Jonas B NielsenDanish National Research Foundation Center for Cardiac Arrhythmia, Copenhagen, Denmark.
Jonas CarlsonThe Center for Integrative Electrocardiology, Arrhythmia Clinic Skåne University Hospital, Lund University (CIEL), Lund, Sweden.
Fredrik HolmqvistThe Center for Integrative Electrocardiology, Arrhythmia Clinic Skåne University Hospital, Lund University (CIEL), Lund, Sweden.ORCID 0000-0001-5369-1296
Arnljot TveitDepartment of Medical Research, Baerum Hospital, Vestre Viken Hospital Trust, Rud, Norway.
Stig HaunsøDanish National Research Foundation Center for Cardiac Arrhythmia, Copenhagen, Denmark.
Jesper H SvendsenDanish National Research Foundation Center for Cardiac Arrhythmia, Copenhagen, Denmark.
Pyotr G PlatonovThe Center for Integrative Electrocardiology, Arrhythmia Clinic Skåne University Hospital, Lund University (CIEL), Lund, Sweden.ORCID 0000-0002-5592-8717
Lund University · SEUniversity of Copenhagen · DKOslo University Hospital · NOVestre Viken Hospital Trust · NO

Funding

ALF: Governmental funding of clinical research within the Swedish healthcare systemArvid Nilsson FoundationDonation funds at Skåne University HospitalThe Danish National Research FoundationThe John and Birth Meyer FoundationThe Norwegian Research CouncilThe Swedish Heart-Ling Foundation
6 · The paper itself

Abstract

backgroundAbnormal P-wave morphology (PWM) has been associated with a history of atrial fibrillation (AF) in earlier studies. Although lone AF is believed to have substantial genetic basis, studies on associations between single nucleotide polymorphisms (SNP) linked to lone AF and PWM have not been reported. We aimed to assess whether SNPs previously associated with lone AF (rs2200733, rs13376333, rs3807989, and rs11047543) are also linked to P-wave abnormalities.

methodsFour SNPs were studied in 176 unrelated individuals with early-onset lone AF (age at onset <50 years), median age 38 years (19-63 years), 149 men. Using sinus rhythm ECG, orthogonal PWM was classified as Type 1-positive in leads X and Y and negative in lead Z, Type 2-positive in leads X and Y and biphasic (-/+) in lead Z, Type 3-positive in lead X and biphasic in lead Y (+/-), and the remaining as atypical.

resultsTwo SNPs were found to be significantly associated with altered P-wave morphology distribution: rs3807989 near the gene CAV1/CAV2 and rs11047543 near the gene SOX5. Both SNPs were associated with a higher risk of non-Type 1 P-wave morphology (rs3807989: OR = 4.8, 95% CI = 2.3-10.2, p < 0.001; rs11047543: OR = 4.7, 95% CI = 1.1-20.5, p = 0.04). No association was observed for rs2200733 and rs13376333.

conclusionIn this study, the two variants rs3807989 and rs11047543, previously associated with PR interval and lone AF, were associated with altered P-wave morphology distribution in patients with early-onset lone AF. These findings suggest that common genetic variants may modify atrial conduction properties.

Indexed as

AdultAtrial FibrillationElectrocardiographyFemaleGenetic Predisposition to DiseaseHeart AtriaHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsYoung Adultatrial fibrillationP-wave morphologySNP

Identifiers

PMID31152482
PMCPMC6931409
OpenAlexW2947970413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.