ArticleJournal of mathematical neuroscience2019
A modified Hodgkin-Huxley model to show the effect of motor cortex stimulation on the trigeminal neuralgia network.
Article in Journal of mathematical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Review
- Exploring the spiking neural autoencoder: from hyperexcitability to noise-driven compensation.Frontiers in systems neuroscience · 2026Article
- The alteration of the sensorimotor network in trigeminal neuralgia after microvascular decompression surgery: a follow-up study using independent component analysis.Frontiers in physiology · 2025Article
- Wave propagation in a light-temperature neural network under adaptive local energy balance.Journal of biological physics · 2024Article
- Quantitative analysis of noninvasive deep temporal interference stimulation: A simulation and experimental study.Heliyon · 2024Article
- Estimation of the Motor Threshold for Near-Rectangular Stimuli Using the Hodgkin-Huxley Model.Computational intelligence and neuroscience · 2021Article
- Optogenetic stimulation of the motor cortex alleviates neuropathic pain in rats of infraorbital nerve injury with/without CGRP knock-down.The journal of headache and pain · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTrigeminal neuralgia (TN) is a severe neuropathic pain, which has an electric shock-like characteristic. There are some common treatments for this pain such as medicine, microvascular decompression or radio frequency. In this regard, transcranial direct current stimulation (tDCS) is another therapeutic method to reduce pain, which has been recently attracting the therapists' attention. The positive effect of tDCS on TN was shown in many previous studies. However, the mechanism of the tDCS effect has remained unclear.
objectiveThis study aims to model the neuronal behavior of the main known regions of the brain participating in TN pathways to study the effect of transcranial direct current stimulation.
methodThe proposed model consists of several blocks: (1) trigeminal nerve, (2) trigeminal ganglion, (3) PAG (periaqueductal gray in the brainstem), (4) thalamus, (5) motor cortex (M1) and (6) somatosensory cortex (S1). Each of these components is represented by a modified Hodgkin-Huxley (HH) model. The modification of the HH model was done based on some neurological facts of pain sodium channels. The input of the model involves any stimuli to the 'trigeminal nerve,' which cause the pain, and the output is the activity of the somatosensory cortex. An external current, which is considered as an electrical current, was applied to the motor cortex block of the model.
resultThe results showed that by decreasing the conductivity of the slow sodium channels (pain channels) and applying tDCS over the M1, the activity of the somatosensory cortex would be reduced. This reduction can cause pain relief.
conclusionThe proposed model provided some possible suggestions about the relationship between the effects of tDCS and associated components in TN, and also the relationship between the pain measurement index, somatosensory cortex activity, and the strength of tDCS.
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