ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2019
Alterations in the skin microbiome are associated with disease severity and treatment in the perioral zone of the skin of infants with atopic dermatitis.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04781036 (The Study of Foot-skin Microbiome and Metabolomics of Thai Naval Cadets With Pitted Keratolysis), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Study of Foot-skin Microbiome and Metabolomics of Thai Naval Cadets With Pitted Keratolysis
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Structural aspects of lesional and non-lesional skin microbiota reveal key community changes in leprosy patients from India.Scientific reports · 2021Trial
- Microbial and metabolic profiles in autism spectrum disorder with atopic dermatitis in children.AMB Express · 2026Article
- Age‑Related Remodeling of the Skin Microbiome in Healthy Women: Site‑Specific Patterns Between Sebaceous and Dry Skin Regions.Clinical, cosmetic and investigational dermatology · 2026Article
- Article
- Impact of maternal obesity and mode of delivery on the newborn skin and oral microbiomes.Journal of medical microbiology · 2025Article
- Analysis of microbial composition in different dry skin areas of Beijing women.Frontiers in microbiology · 2025Article
- Exploration of the Changes in Facial Microbiota of Maskne Patients and Healthy Controls Before and After Wearing Masks Using 16 S rRNA Analysis.Journal of epidemiology and global health · 2024Article
- The inner elbow skin microbiome containsMicrobiome research reports · 2024Article
- Advanced fructo-oligosaccharides improve itching and aberrant epidermal lipid composition in children with atopic dermatitis.Frontiers in microbiology · 2024Article
- Shotgun metagenomic sequencing on skin microbiome indicates dysbiosis exists prior to the onset of atopic dermatitis.Allergy · 2023Article
- Changes in the skin microbiome during male maturation from 0 to 25 years of age.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- The menstrual cycle regularity and skin: irregular menstrual cycle affects skin physiological properties and skin bacterial microbiome in urban Chinese women.BMC women's health · 2023Article
- Shift in skin microbiota of children with atopic dermatitis after topical gentian violet application.Postepy dermatologii i alergologii · 2023Article
- Host ecology drives frog skin microbiome diversity across ecotone in South-Central North America.Frontiers in microbiomes · 2023Article
- CDEMI: Characterizing differences in microbial composition and function in microbiome data.Computational and structural biotechnology journal · 2023Article
- Effects of a PostbioticClinical, cosmetic and investigational dermatology · 2023Article
- Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis.Acta dermato-venereologica · 2022Article
- "Alterations in the Skin Microbiota Are Associated With Symptom Severity in Mycosis Fungoides".Frontiers in cellular and infection microbiology · 2022Article
- Features of the Skin Microbiota in Common Inflammatory Skin Diseases.Life (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atopic dermatitis (AD), a chronic relapsing inflammatory pruritic skin disorder with a unique pathophysiology, has a high incidence in the perioral zone among infants. This study aimed to analyze the association of skin microfloral dynamics with disease severity and treatment of AD in 0-1-year-old infants. Based on the eczema area and severity index, subjects were divided into five groups, i.e., mild, moderate, severe, and severe post-treatment, with a healthy control group, and bacterial density at the perioral lesion, disease severity, and treatment were assessed in 0-1-year-old infants with AD. The perioral lesions were colonized predominantly by Firmicutes, followed in abundance by Proteobacteria, Actinobacteria, and Bacteroidetes. In the phylum Firmicutes, Streptococcus was the most predominant genus. In AD infants, the abundance of Bacteroidetes and Fusobacterium decreased significantly with an increase in disease severity (p < 0.01). The abundance of 6 genera, including Prevotella, decreased significantly with an increase in disease severity (p < 0.05). The abundance of Prevotella melaninogenica decreased gradually with an increase in disease severity and increased after treatment; this trend was reversed for Corynebacterium simulans. A reduction in the abundance of Staphylococcus and an increase in that of skin microflora including Prevotella spp., Staphylococcus epidermidis, and Erwinia dispersa were associated with treatment and clinical improvement. Skin bacterial composition varies with AD severity, and Corynebacterium simulans and Prevotella melaninogenica are positively and negatively correlated with AD severity, respectively. This study provides a theoretical basis to identify potential biomarkers AD occurrence and pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.