Evidence map›Paper›PMID 31152199›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2020

Multipoint left ventricular pacing with large anatomical separation improves reverse remodeling and response to cardiac resynchronization therapy in responders and non-responders to conventional biventricular pacing.

Fabian Schiedat, Dominik Schöne, Assem Aweimer, Leif Bösche, Aydan Ewers, Michael Gotzmann, Polykarpos C Patsalis, Andreas Mügge, Axel Kloppe

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Efficacy of multipoint versus conventional biventricular pacing in CRT: systematic review and meta-analysis of randomized trials.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. A novel risk score to predict survival in advanced heart failure due to cardiac amyloidosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fabian SchiedatDepartment of Cardiology and Angiology, University Hospital Bergmannsheil Bochum of the Ruhr-University, 44789, Bochum, Germany. fschiedat@aol.com.
Dominik SchöneDepartment of Cardiology and Angiology, University Hospital Bergmannsheil Bochum of the Ruhr-University, 44789, Bochum, Germany.
Assem AweimerDepartment of Cardiology and Angiology, University Hospital Bergmannsheil Bochum of the Ruhr-University, 44789, Bochum, Germany.
Leif BöscheDepartment of Cardiology and Angiology, University Hospital Bergmannsheil Bochum of the Ruhr-University, 44789, Bochum, Germany.
Aydan EwersDepartment of Cardiology and Angiology, University Hospital Bergmannsheil Bochum of the Ruhr-University, 44789, Bochum, Germany.
Michael GotzmannDepartment of Cardiology, St. Josef Hospital Bochum, Ruhr University, Bochum, Germany.
Polykarpos C PatsalisDepartment of Cardiology and Angiology, University Hospital Bergmannsheil Bochum of the Ruhr-University, 44789, Bochum, Germany.
Andreas MüggeDepartment of Cardiology and Angiology, University Hospital Bergmannsheil Bochum of the Ruhr-University, 44789, Bochum, Germany.
Axel KloppeDepartment of Cardiology and Angiology, University Hospital Bergmannsheil Bochum of the Ruhr-University, 44789, Bochum, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultipoint pacing [Multipoint™ Pacing (MPP), Abbott] via a single left ventricular lead (Quartet™ LV lead, Abbott) improves acute left ventricular (LV) function and response to cardiac resynchronization therapy (CRT). Aim of this study was to examine additional benefits in terms of LV reverse remodeling and CRT response by activating MPP in responders and non-responders to conventional biventricular pacing (CONV).

methods43 consecutive patients receiving CRT (Quadra Assura MP™, Abbott) received LV dP/dt

results41 patients completed FU (one died of non-cardiac cause and one was lost to FU) and after 6 months CONV, 26 patients (63%) were classified as CRT responders. With MPP, the response rate increased to 90% (p < 0.001). Super-response also improved significantly with MPP compared to CONV (71% vs. 22%; p < 0.005). LV reverse remodeling in terms of LVESV improved significantly with MPP compared to CONV (79 ± 45 ml vs. 103 ± 64 ml; p < 0.001). NYHA-class only improved significantly with CONV relative to baseline (1,8 ± 0,7 vs. 2,7 ± 0,5; p < 0.001), but not further with MPP (1,7 ± 0,6 vs. 1,8 ± 0,7; p = 0.49).

conclusionMultipoint pacing significantly improves response and super-response to CRT as well as LV reverse remodeling compared to conventional biventricular pacing.

Indexed as

Cardiac Resynchronization TherapyVentricular Function, LeftVentricular RemodelingAgedFemaleHeart FailureHumansMaleMiddle AgedProspective StudiesQuality of LifeRecovery of FunctionStroke VolumeTime FactorsTreatment OutcomeVentricular PressureCardiac resynchronization therapyCardiac resynchronization therapy responseCRT optimizationHeart failureLeft ventricular reverse remodelingMultipoint pacing

Identifiers

PMID31152199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.