ReviewPain medicine (Malden, Mass.)2019
Mechanism of Action in Burst Spinal Cord Stimulation: Review and Recent Advances.
Review in Pain medicine (Malden, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 90 citations in OpenAlex.
- Passive recharge burst spinal cord stimulation for the treatment of refractory nonsurgical low back pain: 24-month results from a prospective randomized controlled trial and predictors of success.North American Spine Society journal · 2026Article
- Molecular and Cellular Mechanisms of Spinal Cord Stimulation: Linking Dorsal Horn Circuits, Glia, and ECAP-Guided Therapy.International journal of molecular sciences · 2026Review
- Differential target multiplexed SCS (DTM SCS): a rational hypothesis.Pain medicine (Malden, Mass.) · 2026Review
- [New paradigms in spinal cord stimulation (SCS): technology and clinical evidence].Schmerz (Berlin, Germany) · 2026Review
- Therapy-specific motoneuron activation with epidural and dorsal root ganglion stimulation in spinal cord injury.Journal of neurophysiology · 2026Article
- Integrated hierarchical surface restructuring of assembled electrode arrays for next-generation neural interfaces.PloS one · 2026Article
- Spinal Cord Stimulation: Mechanisms of Action, Indications, Types, Complications.Journal of clinical medicine · 2025Review
- Spinal cord stimulation patterns of care, re-interventions, and costs for private health insurers, Australia, 2011-22: a retrospective observational study.The Medical journal of Australia · 2025Observational
- Role of frequency-dependent and capacitive tissue properties in spinal cord stimulation models.Journal of neural engineering · 2025Article
- The Application of Artificial Intelligence to Enhance Spinal Cord Stimulation Efficacy for Chronic Pain Management: Current Evidence and Future Directions.Current pain and headache reports · 2025Review
- T2 high-signal-intensity zone of the spinal cord dorsal horn in patients treated with spinal cord stimulation for herpes zoster-associated pain: a retrospective case-control study.Journal of anesthesia · 2025Article
- Spinal Cord Stimulation Waveforms for the Treatment of Chronic Pain.Current pain and headache reports · 2024Review
- Pathophysiology of Pain and Mechanisms of Neuromodulation: A Narrative Review (A Neuron Project).Journal of pain research · 2024Review
- Current Neurostimulation Therapies for Chronic Pain Conditions.Current pain and headache reports · 2023Review
- Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- The PATIENT Approach: A New Bundle for the Management of Chronic Pain.Journal of personalized medicine · 2023Review
- Editorial for the Special Issue "Chronic Neuropathic Pain Therapy and Anaesthesia".Medicina (Kaunas, Lithuania) · 2023Article
- Advances in Spinal Cord Stimulation.Bioengineering (Basel, Switzerland) · 2023Review
- Article
- Neuromodulation Therapy for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review.Biomedicines · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis is a comprehensive, structured review synthesizing and summarizing the current experimental data and knowledge about the mechanisms of action (MOA) underlying spinal cord stimulation with the burst waveform (as defined by De Ridder) in chronic pain treatment.
methodsMultiple database queries and article back-searches were conducted to identify the relevant literature and experimental findings for results integration and interpretation. Data from recent peer-reviewed conference presentations were also included for completeness and to ensure that the most up-to-date scientific information was incorporated. Both human and animal data were targeted in the search to provide a translational approach in understanding the clinical relevance of the basic science findings. RESULTS/
conclusionsBurst spinal cord stimulation likely provides pain relief via multiple mechanisms at the level of both the spinal cord and the brain. The specific waveforms and temporal patterns of stimulation both play a role in the responses observed. Differential modulation of neurons in the dorsal horn and dorsal column nuclei are the spinal underpinnings of paresthesia-free analgesia. The burst stimulation pattern also produces different patterns of activation within the brain when compared with tonic stimulation. The latter may have implications for not only the somatic components of chronic pain but also the lateral and affective pathway dimensions as well.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.