Evidence map›Paper›PMID 31152163›Full record

SynthesisNature genetics2019

A catalog of genetic loci associated with kidney function from analyses of a million individuals.

Matthias Wuttke, Yong Li, Man Li, Karsten B Sieber, Mary F Feitosa, Mathias Gorski, Adrienne Tin, Lihua Wang, Audrey Y Chu, Anselm Hoppmann and 319 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 537 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
537citing papers in PubMed, 10 pooled it
72.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

537 citing papers in PubMed, 10 syntheses or guidelines pooled it, 892 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Renal gluconeogenesis: a key metabolic hub in health and kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Review
  19. Article
  20. Multi-Omics Genome-Wide to Explore the Formation and Development Targets for Intracranial Aneurysms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article

477 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

329 authors at 20 institutions in 25 countries.

Matthias WuttkeInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-3420-5082
Yong LiInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-2651-8791
Man LiDivision of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA.ORCID http://orcid.org/0000-0002-3839-0281
Karsten B SieberTarget Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0933-2410
Mathias GorskiDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Adrienne TinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4207-5866
Lihua WangDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Audrey Y ChuGenetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Anselm HoppmannInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Holger KirstenInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-3126-7950
Ayush GiriDivision of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-7786-4670
Jin-Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Gardar SveinbjornssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Bamidele O TayoDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Teresa NutileInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
Christian FuchsbergerEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Jonathan MartenMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6916-2014
Massimiliano CoccaInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.ORCID http://orcid.org/0000-0002-1127-7596
Sahar GhasemiInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Yizhe XuDivision of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA.
Katrin HornInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Damia NoceEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-8450-3518
Sanaz SedaghatDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Zhi YuDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Masato AkiyamaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Saima AfaqDepartment of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Tarunveer S AhluwaliaSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Peter AlmgrenDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-0473-0241
Najaf AminDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Johan ÄrnlövDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Stephan J L BakkerDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Nisha BansalDivision of Nephrology, University of Washington, Seattle, WA, USA.
Daniela BaptistaCardiology, Geneva University Hospitals, Geneva, Switzerland.
Sven BergmannDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6785-9034
Mary L BiggsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Ginevra BiinoInstitute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.ORCID http://orcid.org/0000-0002-9936-946X
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6442-7754
Eric BoerwinkleHuman Genetics Center, University of Texas Health Science Center, Houston, TX, USA.
Mathilde BoisselCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.ORCID http://orcid.org/0000-0001-5719-8749
Erwin P BottingerCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Thibaud S BoutinMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4754-1675
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marco BrumatDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Ralph BurkhardtLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-1924-1202
Adam S ButterworthMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6915-9015
Eric CampanaDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Archie CampbellCenter for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0198-5078
Harry CampbellCenter for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Mickaël CanouilCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.ORCID http://orcid.org/0000-0002-3396-4549
Robert J CarrollDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Eulalia CatamoInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
John C ChambersDepartment of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Miao-Ling CheeSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Miao-Li CheeSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Xu ChenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7299-3238
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Yurong ChengInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Kaare ChristensenUnit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark.ORCID http://orcid.org/0000-0002-5429-5292
Renata CifkovaCenter for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic.
Marina CiulloInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
Maria Pina ConcasInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.ORCID http://orcid.org/0000-0003-3598-2537
James P CookDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4598-0669
Tanguy CorreDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Cinzia Felicita SalaSan Raffaele Research Institute, Milan, Italy.
Daniele CusiInstitute of Biomedical Technologies, National Research Council of Italy, Milan, Italy.
John DaneshDepartment of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
E Warwick DawDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Martin H de BorstDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-4127-8733
Alessandro De GrandiEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Aiko P J de VriesSection of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Frauke DegenhardtInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Graciela DelgadoDepartment of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Ayse DemirkanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Emanuele Di AngelantonioDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Katalin DittrichDepartment of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
Jasmin DiversPublic Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0001-6608-2051
Kai-Uwe EckardtIntensive Care Medicine, Charité, Berlin, Germany.
Georg EhretCardiology, Geneva University Hospitals, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-5730-0675
Paul ElliottDepartment of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-7511-5684
Karlhans EndlichDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
Janine F FelixDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9801-5774
Valencia Hui Xian FooSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0003-1530-5811
Barry I FreedmanSection on Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Sandra Freitag-WolfInstitute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0002-1069-7740
Yechiel FriedlanderSchool of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Philippe FroguelCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.ORCID http://orcid.org/0000-0003-2972-0784
Ron T GansevoortDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
He GaoDepartment of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
Paolo GaspariniInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
J Michael GazianoMassachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.
Vilmantas GiedraitisMolecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Giorgia GirottoInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.ORCID http://orcid.org/0000-0003-4507-6589
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Martin GögeleEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Scott D GordonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-7623-328X
Daniel F GudbjartssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Toomas HallerEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Pavel HametMontreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA.
Catharina A HartmanInterdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Jacklyn N HellwegeVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-7479-0920
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-7309-9473
Andrew A HicksEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.ORCID http://orcid.org/0000-0001-6320-0411
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Wei HuangDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai, China.
Nina Hutri-KähönenDepartment of Pediatrics, Tampere University Hospital, Tampere, Finland.
Shih-Jen HwangNHLBI's Framingham Heart Study, Framingham, MA, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Olafur S IndridasonDivision of Nephrology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.
Erik IngelssonDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Marcus IsingMax Planck Institute of Psychiatry, Munich, Germany.
Vincent W V JaddoeDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-2939-0041
Johanna JakobsdottirThe Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland.
Jost B JonasDepartment of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0003-2972-5227
Peter K JoshiCenter for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-6361-5059
Navya Shilpa JosyulaGeisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0003-2782-8812
Bettina JungDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Candace M KammererDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2841-4761
Masahiro KanaiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Mika KastarinenDepartment of Medicine, Kuopio University Hospital, Kuopio, Finland.
Shona M KerrMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Chiea-Chuen KhorSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1128-4729
Wieland KiessLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Marcus E KleberDepartment of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0003-0663-7275
Wolfgang KoenigDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, Middlesex, UK.
Antje KörnerLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Peter KovacsIntegrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-0290-5423
Aldi T KrajaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Alena KrajcoviechovaCenter for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic.
Holly KramerDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Bernhard K KrämerDepartment of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Florian KronenbergDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-2229-1120
Michiaki KuboRIKEN Center for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan.
Brigitte KühnelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Mikko KuokkanenThe Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Johanna KuusistoDepartment of Medicine, Kuopio University Hospital, Kuopio, Finland.
Martina La BiancaInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Markku LaaksoDepartment of Medicine, Kuopio University Hospital, Kuopio, Finland.
Leslie A LangeDivision of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA.
Carl D LangefeldPublic Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jeannette Jen-Mai LeeSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Benjamin LehneDepartment of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Wolfgang LiebInstitute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.
Lifelines Cohort Study
Su-Chi LimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Lars LindCardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Cecilia M LindgrenNuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4903-9374
Jun LiuDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-5288-3042
Jianjun LiuGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0002-3255-3019
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Susanne LucaeMax Planck Institute of Psychiatry, Munich, Germany.
Mary Ann LukasTarget Sciences-Genetics, GlaxoSmithKline, Albuquerque, NM, USA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Anubha MahajanWellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5585-3420
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Jade MartinsDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0001-6528-8947
Winfried MärzSynlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.
Deborah MascalzoniEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Koichi MatsudaLaboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Christa MeisingerIndependent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Thomas MeitingerDZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Olle MelanderHypertension and Cardiovascular Disease, Department of Clincial Sciences Malmö, Lund University, Malmö, Sweden.
Andres MetspaluEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Evgenia K MikaelsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Yuri MilaneschiDepartment of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
Kozeta MilikuDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Pashupati P MishraDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
V. A. Million Veteran Program
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6721-153X
Nina MononenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Grant W MontgomeryInstitute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia.ORCID http://orcid.org/0000-0002-4140-8139
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Josyf C MychaleckyjCenter for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-2595-0005
Girish N NadkarniCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Matthias NauckDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Kjell NikusDepartment of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
Boting NingDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Raymond NoordamSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Jeffrey O'ConnellUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Michelle L O'DonoghueCardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Isleifur OlafssonDepartment of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
Albertine J OldehinkelInterdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-3925-3913
Marju Orho-MelanderDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Willem H OuwehandDepartment of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Nicholette D PalmerBiochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Runolfur PalssonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Brenda W J H PenninxDepartment of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
Thomas PerlsDepartment of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
Markus PerolaNational Institute for Health and Welfare, Helsinki, Finland.
Mario PirastuInstitute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy.
Nicola PirastuCenter for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-5363-3886
Giorgio PistisDepartment of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
Anna I PodgornaiaGenetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Ozren PolasekFaculty of Medicine, University of Split, Split, Croatia.
Belen PonteService de Néphrologie, Geneva University Hospitals, Geneva, Switzerland.
David J PorteousCenter for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1249-6106
Tanja PoulainLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Peter P PramstallerEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Michael H PreussCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bram P PrinsMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Ton J RabelinkSection of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Dermot F ReillyGenetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Rainer RettigInstitute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
Myriam RheinbergerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3071-7278
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Federica RizziDepartment of Health Sciences, University of Milan, Milano, Italy.
David J RobertsNHS Blood and Transplant, BRC Oxford Haematology Theme; Nuffield Division of Clinical Laboratory Sciences; University of Oxford, Oxford, UK.
Antonietta RobinoInstitute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Peter RossingSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Igor RudanCenter for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6993-6884
Rico RueediDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6713-2214
Daniela RuggieroInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
Kathleen A RyanDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Yasaman SabaMolecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Charumathi SabanayagamSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4042-4719
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland.ORCID http://orcid.org/0000-0001-7563-5324
Erika SalviDepartment of Health Sciences, University of Milan, Milano, Italy.ORCID http://orcid.org/0000-0002-2724-2291
Kai-Uwe SaumDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Helena SchmidtInstitute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Ben SchöttkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Christina-Alexandra SchulzDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Nicole SchupfDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Christian M ShafferDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Yuan ShiSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Albert V SmithFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1942-5845
Blair H SmithDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Nicole SoranzoHuman Genetics, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-1095-3852
Cassandra N SpracklenDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2991-6392
Michael StumvollDepartment of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
Per O SvenssonDepartment of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
Silke SzymczakInstitute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
E-Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Salman M TajuddinLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7919-8528
Nicholas Y Q TanSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Andrej TerenLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Yih-Chung ThamSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Joachim ThieryLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Chris H L ThioDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Hauke ThomsenDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Gudmar ThorleifssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Daniela TonioloSan Raffaele Research Institute, Milan, Italy.
Anke TönjesDepartment of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
Johanne TremblayMontreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada.
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-4275-9328
André G UitterlindenDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Simona VaccargiuInstitute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-2713-686X
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Digna R Velez EdwardDepartment of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-4303-7685
Suzanne VogelezangDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Uwe VölkerDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Peter VollenweiderInternal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Gerard WaeberInternal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Lars WallentinCardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Ya Xing WangBeijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0003-2749-7793
Chaolong WangGenome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Dawn M WaterworthTarget Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Wen Bin WeiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Harvey WhiteGreen Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand.
John B WhitfieldQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-1103-0876
Sarah H WildCenter for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
James F WilsonMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
Mary K WojczynskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Charlene WongDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Tien-Yin WongSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Liang XuBeijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Masayuki YasudaSingapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Laura M Yerges-ArmstrongTarget Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Weihua ZhangDepartment of Cardiology, Ealing Hospital, Middlesex, UK.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Murielle BochudInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA.
Veronique VitartMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4991-3797
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Abbas DehghanDepartment of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Afshin ParsaDivision of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Kevin HoKidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA.
Andrew P MorrisDepartment of Biostatistics, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-6805-6014
Olivier DevuystInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Shreeram AkileshKidney Research Institute, University of Washington, Seattle, WA, USA.
Sarah A PendergrassGeisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1233-7642
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Yukinori OkadaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Osaka, Japan.ORCID http://orcid.org/0000-0002-0311-8472
Todd L EdwardsDepartment of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4318-6119
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Kari StefanssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1676-864X
Adriana M HungDepartment of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-3203-1608
Iris M HeidDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-4059-1779
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Anna KöttgenInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0002-4671-3714
Cristian PattaroEurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu.ORCID http://orcid.org/0000-0002-4119-0109
University Medical Center Groningen · NLNational University of Singapore · SGEurac Research · ITNational Institutes of Health · USdeCODE Genetics (Iceland) · ISErasmus MC · NLAgency for Science, Technology and Research · SGBrigham and Women's Hospital · USSingapore National Eye Center · SGBeijing Tongren Hospital · CNBoston University · USCentre National de la Recherche Scientifique · FRGerman Cancer Research Center · DEJohns Hopkins University · USUniversity of Freiburg · DEUniversity of Iceland · ISUniversity of North Carolina at Chapel Hill · USUppsala University · SEHeidelberg University · DEMalmö University · SE

Funding

Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Genetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2M
Healthy Aging Neighborhoods of Diversity Across LifespanZ01AG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2001 to 2008
$6.8M
Identifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Intramural NIH HHS Z01 AG000513Intramural NIH HHS Z99 AG999999Medical Research Council MC_UU_00007/10Medical Research Council MR/R023484/1NHLBI NIH HHS R01 HL088215NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL120393NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS U01 AG023746NICHD NIH HHS K12 HD043483NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIH HHS S10 OD023680Wellcome Trust 212945/Z/18/Z
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.

Indexed as

Genetic Predisposition to DiseaseQuantitative Trait, HeritableQuantitative Trait LociChromosome MappingGenetic Association StudiesGenome-Wide Association StudyGlomerular Filtration RateHumansInheritance PatternsKidney Function TestsPhenotypePolymorphism, Single NucleotideRenal Insufficiency, ChronicUromodulinWhite PeopleUromodulin

Identifiers

PMID31152163
PMCPMC6698888
OpenAlexW2947278243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.