Evidence map›Paper›PMID 31152160›Full record

ArticleNature genetics2019

Phosphorylation of histone H3.3 at serine 31 promotes p300 activity and enhancer acetylation.

Sara Martire, Aishwarya A Gogate, Amanda Whitmill, Amanuel Tafessu, Jennifer Nguyen, Yu-Ching Teng, Melodi Tastemel, Laura A Banaszynski

Open access · greenAbstract readLetter
In one paragraph

Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 171 citations in OpenAlex.

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  13. H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A-Driven EP300 Expression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Article
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  17. Review
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  19. The role of epigenetics in cancer: From pathways to the clinic.Journal of family medicine and primary care · 2025
    Review
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sara MartireCecil H. and Ida Green Center for Reproductive Biology Sciences and the Division of Basic Research, Department of Obstetrics and Gynecology, Children's Medical Center Research Institute, Hamon Center for Regenerative Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-1570-3476
Aishwarya A GogateCecil H. and Ida Green Center for Reproductive Biology Sciences and the Division of Basic Research, Department of Obstetrics and Gynecology, Children's Medical Center Research Institute, Hamon Center for Regenerative Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Amanda WhitmillCecil H. and Ida Green Center for Reproductive Biology Sciences and the Division of Basic Research, Department of Obstetrics and Gynecology, Children's Medical Center Research Institute, Hamon Center for Regenerative Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Amanuel TafessuCecil H. and Ida Green Center for Reproductive Biology Sciences and the Division of Basic Research, Department of Obstetrics and Gynecology, Children's Medical Center Research Institute, Hamon Center for Regenerative Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jennifer NguyenCecil H. and Ida Green Center for Reproductive Biology Sciences and the Division of Basic Research, Department of Obstetrics and Gynecology, Children's Medical Center Research Institute, Hamon Center for Regenerative Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yu-Ching TengCecil H. and Ida Green Center for Reproductive Biology Sciences and the Division of Basic Research, Department of Obstetrics and Gynecology, Children's Medical Center Research Institute, Hamon Center for Regenerative Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Melodi TastemelCecil H. and Ida Green Center for Reproductive Biology Sciences and the Division of Basic Research, Department of Obstetrics and Gynecology, Children's Medical Center Research Institute, Hamon Center for Regenerative Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Laura A BanaszynskiCecil H. and Ida Green Center for Reproductive Biology Sciences and the Division of Basic Research, Department of Obstetrics and Gynecology, Children's Medical Center Research Institute, Hamon Center for Regenerative Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. laura.banaszynski@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-5189-8848
Children's Medical Center · US

Funding

Chromatin Dynamics and Genome RegulationR35GM124958 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Laura Banaszynski · 2017 to 2026
$4.4M
NIGMS NIH HHS R35 GM124958
6 · The paper itself

Abstract

The histone variant H3.3 is enriched at enhancers and active genes, as well as repeat regions such as telomeres and retroelements, in mouse embryonic stem cells (mESCs)

Indexed as

Enhancer Elements, GeneticGene Expression RegulationAcetylationAnimalsCell DifferentiationEmbryonic Stem CellsHistonesMicep300-CBP-Associated Factorp300-CBP Transcription FactorsPhosphorylationProtein Processing, Post-TranslationalSerineHistonesp300-CBP-Associated Factorp300-CBP Transcription FactorsSerine

Identifiers

PMID31152160
PMCPMC6598431
OpenAlexW2946885478

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.