ArticleProceedings of the National Academy of Sciences of the United States of America2019
A major role for noncoding regulatory mutations in the evolution of enzyme activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
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- Quantifying Transcriptome Turnover on Phylogenies by Modeling Gene Expression as a Binary Trait.Molecular biology and evolution · 2025Article
- Demonstration of in vivo engineered tandem duplications of varying sizes using CRISPR and recombinases in Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Demonstration ofbioRxiv : the preprint server for biology · 2023Article
- A tandem duplication in Drosophila melanogaster shows enhanced expression beyond the gene copy number.Genetics · 2022Article
- Spontaneous mutation rate estimates for the principal malaria vectors Anopheles coluzzii and Anopheles stephensi.Scientific reports · 2022Article
- Growth of Biological Complexity from Prokaryotes to Hominids Reflected in the Human Genome.International journal of molecular sciences · 2021Article
- Molecular Mechanisms of the SLC13A5 Gene Transcription.Metabolites · 2021Review
- TERT promoter alterations could provide a solution for Peto's paradox in rodents.Scientific reports · 2020Article
- The origin and diversification of a novel protein family in venomous snakes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Fitness effects but no temperature-mediated balancing selection at the polymorphicProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo.eLife · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The quantitative evolution of protein activity is a common phenomenon, yet we know little about any general mechanistic tendencies that underlie it. For example, an increase (or decrease) in enzyme activity may evolve from changes in protein sequence that alter specific activity, or from changes in gene expression that alter the amount of protein produced. The latter in turn could arise via mutations that affect gene transcription, posttranscriptional processes, or copy number. Here, to determine the types of genetic changes underlying the quantitative evolution of protein activity, we dissected the basis of ecologically relevant differences in
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