ArticleProceedings of the National Academy of Sciences of the United States of America2019
Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- T-cell differentiation stage block bias confers hypermethylation and mediastinal preference in T-cell lymphoblastic lymphoma.Clinical and translational medicine · 2025Article
- Protein phosphatases in systemic autoimmunity.Immunometabolism (Cobham, Surrey) · 2025Review
- Protein Phosphatase 2A Promotes CD8Research (Washington, D.C.) · 2025Article
- A landscape of X-inactivation during human T cell development.Nature communications · 2024Article
- METTL3 governs thymocyte development and thymic involution by regulating ferroptosis.Nature aging · 2024Article
- PP2A catalytic subunit alpha is critically required for CD8European journal of immunology · 2024Article
- Review
- PP2A catalytic subunit alpha is critically required for CD8bioRxiv : the preprint server for biology · 2024Article
- Protein phosphatase 2A propels follicular T helper cell development in lupus.Journal of autoimmunity · 2023Article
- TOX deficiency facilitates the differentiation of IL-17A-producing γδ T cells to drive autoimmune hepatitis.Cellular & molecular immunology · 2022Article
- LncRNA and mRNA expression associated with myasthenia gravis in patients with thymoma.Thoracic cancer · 2022Article
- SRSF1 serves as a critical posttranscriptional regulator at the late stage of thymocyte development.Science advances · 2021Article
- Transcription factor Hap5 induces gsh2 expression to enhance 2-phenylethanol tolerance and production in an industrial yeast Candida glycerinogenes.Applied microbiology and biotechnology · 2020Article
- Functional characterization of acyl-CoA binding protein in Neospora caninum.Parasites & vectors · 2020Article
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of thymocytes to mature T cells in the thymus is tightly controlled by cellular selection, in which only a small fraction of thymocytes equipped with proper quality of TCRs progress to maturation. It is pivotal to protect the survival of the few T cells, which pass the selection. However, the signaling events, which safeguard the cell survival in thymus, are not totally understood. In this study, protein Ser/Thr phosphorylation in thymocytes undergoing positive selection is profiled by mass spectrometry. The results revealed large numbers of dephosphorylation changes upon T cell receptor (TCR) activation during positive selection. Subsequent substrate analysis pinpointed protein phosphatase 2A (PP2A) as the enzyme responsible for the dephosphorylation changes in developing thymocytes. PP2A catalytic subunit α (
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