ArticleeNeuro
Slow NMDA-Mediated Excitation Accelerates Offset-Response Latencies Generated via a Post-Inhibitory Rebound Mechanism.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
- Deep Brain Stimulation Induces Antidepressant Effects by Restoring High-Fidelity Communication in the BNST-NAc Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Coordination of spike timing among the neurons of the cerebellum.Research square · 2026Article
- Coordination of spike timing among the neurons of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Article
- Characterizing optogenetically mediated rebound effects in anaesthetized mouse primary visual cortex.The Journal of physiology · 2025Article
- Distinct cell classes in the superior paraolivary nucleus (SPN) region in the gerbil auditory brainstem revealed by in vivo physiological and anatomical characterization.Hearing research · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Oligodendrocyte arrangement, identification and morphology in the developing superior olivary complex.Frontiers in cellular neuroscience · 2025Article
- A new function of offset response in the primate auditory cortex: marker of temporal integration.Communications biology · 2024Article
- Effects of Age on Responses of Principal Cells of the Mouse Anteroventral Cochlear Nucleus in Quiet and Noise.eNeuro · 2024Article
- Dissociable Roles of the Auditory Midbrain and Cortex in Processing the Statistical Features of Natural Sound Textures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents: A simulation study.PLoS computational biology · 2024Article
- Post-Inhibitory Rebound Firing of Dorsal Root Ganglia Neurons.Journal of pain research · 2022Article
- Simple models including energy and spike constraints reproduce complex activity patterns and metabolic disruptions.PLoS computational biology · 2020Article
- Developmentally Regulated Rebound Depolarization Enhances Spike Timing Precision in Auditory Midbrain Neurons.Frontiers in cellular neuroscience · 2020Article
- Periodicity Pitch Perception.Frontiers in neuroscience · 2020Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In neural circuits, action potentials (spikes) are conventionally caused by excitatory inputs whereas inhibitory inputs reduce or modulate neuronal excitability. We previously showed that neurons in the superior paraolivary nucleus (SPN) require solely synaptic inhibition to generate their hallmark offset response, a burst of spikes at the end of a sound stimulus, via a post-inhibitory rebound mechanism. In addition SPN neurons receive excitatory inputs, but their functional significance is not yet known. Here we used mice of both sexes to demonstrate that in SPN neurons, the classical roles for excitation and inhibition are switched, with inhibitory inputs driving spike firing and excitatory inputs modulating this response. Hodgkin-Huxley modeling suggests that a slow, NMDA receptor (NMDAR)-mediated excitation would accelerate the offset response. We find corroborating evidence from
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.