Evidence map›Paper›PMID 31152063›Full record

ArticleThe Journal of biological chemistry2019

Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.

Chad E Cragle, Melanie C MacNicol, Stephanie D Byrum, Linda L Hardy, Samuel G Mackintosh, William A Richardson, Nicola K Gray, Gwen V Childs, Alan J Tackett, Angus M MacNicol

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Isoform-Specific Localization Diversifies Human MSI2 Function.bioRxiv : the preprint server for biology · 2026
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  6. Review
  7. miR-107 repressesMolecular therapy. Nucleic acids · 2025
    Article
  8. Article
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  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Cell cycle (Georgetown, Tex.) · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Chad E CragleDepartment of Neurobiology and Developmental Sciences.
Melanie C MacNicolDepartment of Neurobiology and Developmental Sciences,; Center for Translational Neuroscience.
Stephanie D ByrumDepartment of Biochemistry and Molecular Biology,; Arkansas Children's Research Institute.
Linda L HardyDepartment of Neurobiology and Developmental Sciences.
Samuel G MackintoshDepartment of Biochemistry and Molecular Biology.
William A RichardsonMRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, United Kingdom.
Nicola K GrayMRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, United Kingdom.
Gwen V ChildsDepartment of Neurobiology and Developmental Sciences,; Center for Translational Neuroscience.
Alan J TackettDepartment of Biochemistry and Molecular Biology,; Arkansas Children's Research Institute.
Angus M MacNicolDepartment of Neurobiology and Developmental Sciences,; Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 and. Electronic address: Angus@UAMS.edu.
Health and Human Development (2HD) Research Network · CMCenter for Translational Molecular Medicine · NLMRC Centre for Reproductive Health · GBUniversity of Edinburgh · GB

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett · 2012 to 2026
$60.9M
Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Samrat Roy Choudhury · 2017 to 2026
$27.6M
Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
PHYSIOLOGICAL DISTURBANCES ASSOCIATED WITH NEONATAL INTRAVENTRICULAR HEMORRHAGEP20RR020146 · NCRR · UNIV OF ARKANSAS FOR MED SCIS · PI GARCIA-RILL, EDGAR E. · 2004 to 2011
$17.2M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Telemedicine CoreP30GM110702 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI GARCIA-RILL, EDGAR E. · 2014 to 2018
$6.1M
Center for Translational NeuroscienceP20GM103425 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI GARCIA-RILL, EDGAR E. · 2012 to 2013
$4.1M
Control of pituitary cell plasticity through regulated mRNA translationR01HD093461 · NICHD · UNIV OF ARKANSAS FOR MED SCIS · PI CHILDS, GWEN V, MACNICOL, ANGUS M · 2018 to 2022
$3.1M
Post-transcriptional Pathways that Signal Leptin Regulation of GonadotropesR01HD087057 · NICHD · UNIV OF ARKANSAS FOR MED SCIS · PI CHILDS, GWEN V, MACNICOL, ANGUS M · 2016 to 2020
$2.3M
Tropic Roles for Leptin in the Maturation of SomatotropesR01DK113776 · NIDDK · UNIV OF ARKANSAS FOR MED SCIS · PI CHILDS, GWEN V, MACNICOL, ANGUS M · 2017 to 2020
$1.8M
Orbitrap Fusion Tribrid Mass SpectrometerS10OD018445 · OD · UNIV OF ARKANSAS FOR MED SCIS · PI MACKINTOSH, SAMUEL G. · 2015 to 2015
$856k
Arkansas Center for Clinical Translational ResearchKL2TR000063 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$459k
Biotechnology and Biological Sciences Research Council BB/J01687X/1Medical Research Council MR/J003069/1Medical Research Council MR/N022556/1Medical Research Council MR/P02419X/1NCATS NIH HHS KL2 TR000063NCATS NIH HHS UL1 TR000039NCATS NIH HHS UL1 TR003107NCRR NIH HHS P20 RR020146NICHD NIH HHS R01 HD087057NICHD NIH HHS R01 HD093461NIDDK NIH HHS R01 DK113776NIGMS NIH HHS P20 GM103425NIGMS NIH HHS P20 GM103429NIGMS NIH HHS P20 GM121293NIGMS NIH HHS P30 GM110702NIH HHS S10 OD018445
6 · The paper itself

Abstract

The Musashi family of mRNA translational regulators controls both physiological and pathological stem cell self-renewal primarily by repressing target mRNAs that promote differentiation. In response to differentiation cues, Musashi can switch from a repressor to an activator of target mRNA translation. However, the molecular events that distinguish Musashi-mediated translational activation from repression are not understood. We have previously reported that Musashi function is required for the maturation of

Indexed as

AnimalsCell CycleCell DifferentiationNerve Tissue ProteinsOocytesOogenesisPoly(A)-Binding Protein IPoly(A)-Binding ProteinsPolyadenylationProtein BiosynthesisRibonucleoproteinsRNA-Binding ProteinsRNA, MessengerSignal TransductionXenopus laevisXenopus ProteinsMsi1 protein, XenopusNerve Tissue ProteinsPABPC4 protein, XenopusPoly(A)-Binding Protein IPoly(A)-Binding ProteinsRibonucleoproteinsRNA-Binding ProteinsRNA, MessengerXenopus Proteinscell plasticityinteractome analysismRNAMusashioocytePABPpolyadenylationself-renewalstem cellstranslation control

Identifiers

PMID31152063
PMCPMC6635449
OpenAlexW2947541121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.