Evidence map›Paper›PMID 31152062›Full record

ArticleThe Journal of biological chemistry2019

The Ca-loop in thymidylate kinase is critical for growth and contributes to pyrimidine drug sensitivity of

Chang-Yu Huang, Yee-Chun Chen, Betty A Wu-Hsieh, Jim-Min Fang, Zee-Fen Chang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. EditingBiomolecules · 2026
    Review
  4. Article
  5. Antifungal Activity of 5-Fluorouridine AgainstMolecules (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. CRISPR-Based Genetic Manipulation ofFrontiers in genome editing · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chang-Yu HuangFrom the Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Linong Street, Taipei 11221.
Yee-Chun Chenthe National Taiwan University Hospital and College of Medicine.
Betty A Wu-Hsiehthe Graduate Institute of Immunology, College of Medicine, National Taiwan University, Jen-Ai Road, Taipei 10051, and.
Jim-Min Fangthe Department of Chemistry, National Taiwan University, Taipei City 10617, Taiwan.
Zee-Fen ChangFrom the Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Linong Street, Taipei 11221, zfchang@ntu.edu.tw.
National Taiwan University · TWNational Taiwan University Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The yeast

Indexed as

Amino Acid SequenceAntifungal AgentsCandida albicansFungal ProteinsGene EditingHumansKineticsMicrobial Sensitivity TestsNucleoside-Phosphate KinasePyrimidinesRecombinant ProteinsSequence AlignmentSubstrate SpecificityUridineUridine Monophosphate5-fluorouridineAntifungal AgentsdTMP kinaseFungal ProteinsNucleoside-Phosphate KinasePyrimidinesRecombinant ProteinsUridineUridine MonophosphateCandida albicansDNA damagedrug resistancenucleoside/nucleotide analoguesubstrate specificitythymidylate kinase

Identifiers

PMID31152062
PMCPMC6615673
OpenAlexW2947966470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.