Evidence map›Paper›PMID 31152000›Full record

ArticleJournal of lipid research2019

Intestinal basolateral lipid substrate transport is linked to chylomicron secretion and is regulated by apoC-III.

Diana Li, Cayla N Rodia, Zania K Johnson, Minkyung Bae, Angelika Muter, Amy E Heussinger, Nicholas Tambini, Austin M Longo, Hongli Dong, Ji-Young Lee and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Functional characteristics of a pig 2D intestinal organoid model as anJournal of animal science and technology · 2026
    Article
  3. The Use of Organoid Cultures in Advancing Nutrition Research.Advances in nutrition (Bethesda, Md.) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Quartet of APOCs and the Different Roles They Play in Diabetes.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Review
  9. Review
  10. Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022
    Article
  11. Review
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Diana LiDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT.
Cayla N RodiaDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT.
Zania K JohnsonDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT.
Minkyung BaeDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT.
Angelika MuterDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT.
Amy E HeussingerDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT.
Nicholas TambiniDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT.
Austin M LongoDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT.
Hongli DongDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT.
Ji-Young LeeDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT.
Alison B KohanDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT. Electronic address: alison.kohan@uconn.edu.
University of Connecticut · US

Funding

LIPID, LIPOPROTEIN, AND GLUCOSE METABOLISM COREU24DK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2001 to 2015
$12.9M
Determining the Role of apoC-III in the Immune SystemR01DK118239 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOHAN, ALISON BLOOM · 2019 to 2023
$2.3M
A unique role for apoC-III in intestinal lipoprotein synthesis and secretionK01DK101663 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI KOHAN, ALISON BLOOM · 2014 to 2018
$779k
Determining the Mechanism for ApoC-III Stimulation of IL-10 and Tregs in the Intestine: Is this Novel Effect Beneficial?R03DK116011 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOHAN, ALISON BLOOM · 2019 to 2020
$238k
NIDDK NIH HHS K01 DK101663NIDDK NIH HHS R01 DK118239NIDDK NIH HHS R03 DK116011NIDDK NIH HHS U24 DK059630
6 · The paper itself

Abstract

Chylomicron metabolism is critical for determining plasma levels of triacylglycerols (TAGs) and cholesterol, both of which are risk factors for CVD. The rates of chylomicron secretion and remnant clearance are controlled by intracellular and extracellular factors, including apoC-III. We have previously shown that human apoC-III overexpression in mice (

Indexed as

AnimalsApolipoprotein C-IIICholesterolChromatography, Thin LayerChylomicronsFemaleFlow CytometryIntestinal MucosaLipoproteinsMaleMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionTriglyceridesApolipoprotein C-IIICholesterolChylomicronsLipoproteinsTriglyceridesapolipoprotein C-IIIchylomicroncytosolic lipid dropletdietary fat absorptionenterocytefatty acid oxidationlow density lipoprotein receptor

Identifiers

PMID31152000
PMCPMC6718441
OpenAlexW2947021216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.