Evidence map›Paper›PMID 31151930›Full record

ArticleEBioMedicine2019

MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition.

Catriona Hilton, Matt J Neville, Laura B L Wittemans, Marijana Todorcevic, Katherine E Pinnick, Sara L Pulit, Jian'an Luan, Agné Kulyté, Ingrid Dahlman, Nicholas J Wareham and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Catriona HiltonOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
Matt J NevilleOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK. Electronic address: matthew.neville@ocdem.ox.ac.uk.
Laura B L WittemansWellcome Trust Centre for Human Genetics, Oxford University, Oxford OX3 7BN, UK; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Marijana TodorcevicOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
Katherine E PinnickOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.
Sara L PulitBig Data Institute, University of Oxford, Oxford OX3 7FZ, UK; Wellcome Trust Centre for Human Genetics, Oxford University, Oxford OX3 7BN, UK; Department of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Jian'an LuanMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Agné KulytéDepartment of Medicine (H7), Karolinska Institutet at Karolinska University Hospital - Huddinge, 141 86 Stockholm, Sweden.
Ingrid DahlmanDepartment of Medicine (H7), Karolinska Institutet at Karolinska University Hospital - Huddinge, 141 86 Stockholm, Sweden.
Nicholas J WarehamMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Luca A LottaMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Peter ArnerDepartment of Medicine (H7), Karolinska Institutet at Karolinska University Hospital - Huddinge, 141 86 Stockholm, Sweden.
Cecilia M LindgrenBig Data Institute, University of Oxford, Oxford OX3 7FZ, UK; Wellcome Trust Centre for Human Genetics, Oxford University, Oxford OX3 7BN, UK.
Claudia LangenbergMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK. Electronic address: Fredrik.karpe@ocdem.ox.ac.uk.
Churchill Hospital · GBUniversity of Cambridge · GBCentre for Human Genetics · GBKarolinska University Hospital · SE

Funding

Medical Research Council G1001959Medical Research Council MC_UU_12015/1Wellcome Trust
6 · The paper itself

Abstract

backgroundAbdominal fat mass is associated with metabolic risk whilst gluteal femoral fat is paradoxically protective. MicroRNAs are known to be necessary for adipose tissue formation and function but their role in regulating human fat distribution remains largely unexplored.

methodsAn initial microarray screen of abdominal subcutaneous and gluteal adipose tissue, with validatory qPCR, identified microRNA-196a as being strongly differentially expressed between gluteal and abdominal subcutaneous adipose tissue.

findingsWe found that rs11614913, a SNP within pre-miR-196a-2 at the HOXC locus, is an eQTL for miR-196a expression in abdominal subcutaneous adipose tissue (ASAT). Observations in large cohorts showed that rs11614913 increased waist-to-hip ratio, which was driven specifically by an expansion in ASAT. In further experiments, rs11614913 was associated with adipocyte size. Functional studies and transcriptomic profiling of miR-196a knock-down pre-adipocytes revealed a role for miR-196a in regulating pre-adipocyte proliferation and extracellular matrix pathways.

interpretationThese data identify a role for miR-196a in regulating human body fat distribution. FUND: This work was supported by the Medical Research Council and Novo Nordisk UK Research Foundation (G1001959) and Swedish Research Council. We acknowledge the OBB-NIHR Oxford Biomedical Research Centre and the British Heart Foundation (BHF) (RG/17/1/32663). Work performed at the MRC Epidemiology Unit was funded by the United Kingdom's Medical Research Council through grants MC_UU_12015/1, MC_PC_13046, MC_PC_13048 and MR/L00002/1.

Indexed as

Gene Expression RegulationAdipocytesAdipose TissueAdiposityAdultAllelesCell LineExtracellular MatrixFemaleGene Expression ProfilingHumansMaleMicroRNAsMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociMicroRNAsMIRN196 microRNA, humanAbdominalAdipocyteBody fat distributionGlutealHuman adipose tissueMicroRNA

Identifiers

PMID31151930
PMCPMC6607082
OpenAlexW2947004080

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.