ReviewJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2019
Pathophysiology of Lacunar Stroke: History's Mysteries and Modern Interpretations.
Review in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 72 citations in OpenAlex.
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- High-Resolution Vessel Wall Imaging Can Differentiate Between Branch Atheromatous Disease From Small Vessel Ischemic Disease.Journal of the American Heart Association · 2026Article
- Promoter hypomethylation ofFrontiers in genetics · 2026Article
- Simultaneous subarachnoid hemorrhage and cerebral infarction due to aneurysm rupture and occlusion of the parent terminal artery: A cause of angiogram-negative non-perimesencephalic subarachnoid hemorrhage.Neurosurgical review · 2025Article
- Effects of Heavy Alcohol Use on Acute Intracerebral Hemorrhage and Cerebral Small Vessel Disease.Neurology · 2025Article
- A four-year assessment of demographic information, clinical presentations, risk factors and outcomes in lacunar stroke patients.BMC neurology · 2025Article
- Dementia from Small Vessel Disease Versus Alzheimer's Disease: Separate Diseases or Distinct Manifestations of Cerebral Capillopathy Due to Blood-Brain Barrier Dysfunction? A Pilot Study.International journal of molecular sciences · 2025Article
- Left atrial appendage closure in patients with atrial fibrillation and acute ischaemic stroke despite anticoagulation.Stroke and vascular neurology · 2025Article
- Characterizing the underlying microangiopathy of deep cerebellar intracerebral hemorrhage.Journal of neurology · 2025Article
- Vascular endothelial cadherin dysfunction: A predictor of hypertensive nonlobar intracerebral hemorrhage.Surgical neurology international · 2025Article
- FLAIR signal intensity ratio predicts small subcortical infarct early neurologic deterioration: a cross-sectional study.Neuroradiology · 2024Article
- Development and Validation of a Nomogram for Predicting Lacunar Infarction in Patients with Hypertension.International journal of general medicine · 2024Article
- Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update.Frontiers in immunology · 2024Review
- Differential blood-based biomarkers of subcortical and deep brain small vessel disease.Therapeutic advances in neurological disorders · 2024Article
- Mechanistic Implications of Cortical Superficial Siderosis in Patients With Mixed Location Intracerebral Hemorrhage and Cerebral Microbleeds.Neurology · 2023Article
- Article
- Perfusion Status in Lacunar Stroke: A Pathophysiological Issue.Diagnostics (Basel, Switzerland) · 2023Review
- Risk of recurrent stroke and mortality after cryptogenic stroke in diabetic patients.Heart and vessels · 2023Article
- [Overview of infectious and non-infectious diseases in French Guiana in 2022].Medecine tropicale et sante internationale · 2023Review
- Improving detection of cerebral small vessel disease aetiology in patients with isolated lobar intracerebral haemorrhage.Stroke and vascular neurology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Since the term "lacune" was adopted in the 1800s to describe infarctions from cerebral small vessels, their underlying pathophysiological basis remained obscure until the 1960s when Charles Miller Fisher performed several autopsy studies of stroke patients. He observed that the vessels displayed segmental arteriolar disorganization that was associated with vessel enlargement, hemorrhage, and fibrinoid deposition. He coined the term "lipohyalinosis" to describe the microvascular mechanism that engenders small subcortical infarcts in the absence of a compelling embolic source. Since Fisher's early descriptions of lipohyalinosis and lacunar stroke (LS), there have been many advancements in the understanding of this disease process. Herein, we review lipohyalinosis as it relates to modern concepts of cerebral small vessel disease (cSVD). We discuss clinical classifications of LS as well as radiographic definitions based on modern neuroimaging techniques. We provide a broad and comprehensive overview of LS pathophysiology both at the vessel and parenchymal levels. We also comment on the role of biomarkers, the possibility of systemic disease processes, and advancements in the genetics of cSVD. Lastly, we assess preclinical models that can aid in studying LS disease pathogenesis. Enhanced understanding of this highly prevalent disease will allow for the identification of novel therapeutic targets capable of mitigating disease sequelae.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.