ArticleNeuron2019
Thermoregulation via Temperature-Dependent PGD
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 77 citations in OpenAlex.
- Thermal challenge and food intake: Mutual regulatory mechanisms.Neural regeneration research · 2026Article
- Delta-Band Dynamics of CaMKI-Positive Preoptic Neurons Encode Thermal Homeostatic Information.Neuroscience bulletin · 2026Article
- Disrupted temperature-sleep coupling mechanism in a Dravet syndrome mouse model.Nature communications · 2026Article
- FADS1 contributes to anesthesia/surgery-induced cognitive impairment by aggravating omega-6 fatty acid metabolic disruption in aged mice.Journal of neuroinflammation · 2026Article
- The neural thermostat malfunction: revisiting heatstroke through the lens of warm-sensitive neuron dysregulation.Frontiers in cellular neuroscience · 2026Review
- Unsaturated fat alters clock phosphorylation to align rhythms to the season in mice.Science (New York, N.Y.) · 2025Article
- Molecular basis for ligand recognition and receptor activation of the prostaglandin D2 receptor DP1.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Estradiol Reverses Ovariectomy-Induced Disruption of Hypothalamic Gene Expression and Behavior via Modulation of Gonadotropin Releasing Hormone and Calcium Signaling Pathways.Animals : an open access journal from MDPI · 2025Article
- Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females.Molecular metabolism · 2025Article
- PRTS: Predicting Single-Cell Spatial Transcriptomic Maps from Histological Images.Research (Washington, D.C.) · 2025Article
- The telencephalon is a neuronal substrate for systemic inflammatory responses in teleosts via polyamine metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Vertebrate behavioral thermoregulation: knowledge and future directions.Neurophotonics · 2024Review
- Hypothalamic Neuromodulation and Control of the Dermal Surface Temperature of Livestock during Hyperthermia.Animals : an open access journal from MDPI · 2024Review
- Identifying hypothermia death in a mouse model by ATR-FTIR.International journal of legal medicine · 2024Article
- Specific and Nonuniform Brain States during Cold Perception in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Prostaglandin ETemperature (Austin, Tex.) · 2024Review
- Patch-seq: Advances and Biological Applications.Cellular and molecular neurobiology · 2023Review
- The Challenge of Global Warming in Water Buffalo Farming: Physiological and Behavioral Aspects and Strategies to Face Heat Stress.Animals : an open access journal from MDPI · 2023Review
- Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.Scientific reports · 2023Review
- Article
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Body temperature control is essential for survival. In mammals, thermoregulation is mediated by the preoptic area of anterior hypothalamus (POA), with ∼30% of its neurons sensitive to brain temperature change. It is still unknown whether and how these temperature-sensitive neurons are involved in thermoregulation, because for eight decades they have only been identified via electrophysiological recording. By combining single-cell RNA-seq with whole-cell patch-clamp recordings, we identified Ptgds as a genetic marker for temperature-sensitive POA neurons. Then, we demonstrated these neurons' role in thermoregulation via chemogenetics. Given that Ptgds encodes the enzyme that synthesizes prostaglandin D2 (PGD
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.