Evidence map›Paper›PMID 31151757›Full record

ArticleTrends in genetics : TIG2019

Beneficial Noncancerous Mutations in Liver Disease.

Miryam Müller, Stuart J Forbes, Thomas G Bird

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in genetics : TIG, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Healthy lifestyle? or just the right genetic mutations.Cell cycle (Georgetown, Tex.) · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Miryam MüllerCancer Research UK Beatson Institute, Glasgow, G61 1BD, UK.
Stuart J ForbesMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH164TJ, UK; MRC Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. Electronic address: stuart.forbes@ed.ac.uk.
Thomas G BirdCancer Research UK Beatson Institute, Glasgow, G61 1BD, UK; MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH164TJ, UK.

Funding

Cancer Research UK 26813
6 · The paper itself

Abstract

Chronic liver disease results in fibrosis and cancer. While injury is associated with mutational burden, a recent study (Zhu et al. Cell 2019;177:608-621) highlights that not all positively selected mutations in the liver are precancerous. Indeed, some may be beneficial to the ability of the liver to not only withstand injury , but also to regenerate.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsHumansLiverMutationRegeneration

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.