ArticleTrials2019
RTS,S malaria vaccine pilot studies: addressing the human realities in large-scale clinical trials.
Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Factors Associated with Trust and Likelihood of Participation in Pandemic-Related Clinical Trials Among Blacks in the U.S. Deep South.Journal of racial and ethnic health disparities · 2026Article
- Awareness, acceptability and determinants of the new malaria vaccine among caregivers of under-five children in Asaba, Nigeria: a multi-centre cross-sectional study.Malaria journal · 2026Article
- Effectiveness of the Smart Home Model for Integrated Malaria Prevention: A Case-Control Study in Oyam District, Uganda.Journal of tropical medicine · 2026Article
- Caregiver acceptability of seasonal malaria chemoprevention in two districts in the Upper West region, Ghana: a cross-sectional study.Malaria journal · 2025Article
- Designing and deploying caller tunes on mobile phones to promote malaria vaccine uptake in Africa: can the technology acceptance model (TAM) help?Malaria journal · 2024Review
- Caregiver acceptance of malaria vaccination for children under 5 years of age and associated factors: cross-sectional household survey, Guinea and Sierra Leone, 2022.Malaria journal · 2023Article
- Unravelling factors associated with malaria parasitaemia among children 6-24 months to inform malaria interventions in Nigeria: evidence from 2021 Malaria Indicator Survey.Malaria journal · 2023Article
- Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design.NPJ vaccines · 2023Article
- Barriers and facilitators to nationwide implementation of the malaria vaccine in Ghana.Health policy and planning · 2023Article
- Article
- Predictors of malaria vaccine uptake among children 6-24 months in the Kassena Nankana Municipality in the Upper East Region of Ghana.Malaria journal · 2022Article
- Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventions.Infectious diseases of poverty · 2022Article
- Novel malaria vaccines.Human vaccines & immunotherapeutics · 2021Article
- Immunosuppression in Malaria: DoPathogens (Basel, Switzerland) · 2021Review
- Article
- A Lab-On-chip Tool for Rapid, Quantitative, and Stage-selective Diagnosis of Malaria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Protein-based antigen presentation platforms for nanoparticle vaccines.NPJ vaccines · 2021Review
- Impacts of Ecology, Parasite Antigenic Variation, and Human Genetics on RTS,S/AS01e Malaria Vaccine Efficacy.Current epidemiology reports · 2021Review
- Will More of the Same Achieve Malaria Elimination? Results from an Integrated Macroeconomic Epidemiological Demographic Model.The American journal of tropical medicine and hygiene · 2020Article
- Nanobiotechnological modules as molecular target tracker for the treatment and prevention of malaria: options and opportunity.Drug delivery and translational research · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
A malaria vaccine as part of the integrated malaria control and elimination efforts will have a major impact on public health in sub-Sahara Africa. The first malaria vaccine, RTS,S, now enters pilot implementation in three African countries. These pilot implementation studies are being initiated in Kenya, Malawi, and Ghana to inform the broader roll-out recommendation. Based on the malaria vaccine clinical trial experiences, key ethical practices for effective clinical trial research in low-resource settings are described. For successful vaccine integration into malaria intervention programs, the relational dynamics between researchers and trial communities must be made explicit. Incorporating community values and returning to research practices that serve the intended benefactors are key strategies that address the human realities in large-scale clinical trials and pilot implementation, leading to positive public health outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.