Evidence map›Paper›PMID 31151466›Full record

ArticleStem cell research & therapy2019

Feasibility of repairing full-thickness skin defects by iPSC-derived epithelial stem cells seeded on a human acellular amniotic membrane.

Huateng Zhou, Lixiang Wang, Cui Zhang, Jintao Hu, Jianlin Chen, Weibin Du, Fei Liu, Weifan Ren, Jinfu Wang, Renfu Quan

Open access · goldAbstract read
In one paragraph

Article in Stem cell research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. PURIONJournal of biomaterials applications · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Feasibility of repairing skin defects by VEGFJournal of cellular and molecular medicine · 2023
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Huateng ZhouClinical Medical College, Zhejiang Chinese Medical University, Zhejiang, 310053, Hangzhou, China.
Lixiang WangDepartment of Orthopedic Surgery, Xiaoshan Traditional Chinese Medical Hospital, Zhejiang, 311200, Hangzhou, China.
Cui ZhangLaboratory of Stem Cells, Institute of Cell Biology, College of Life Sciences, Zhejiang University, Zhejiang, 310058, Hangzhou, China.
Jintao HuClinical Medical College, Zhejiang Chinese Medical University, Zhejiang, 310053, Hangzhou, China.
Jianlin ChenLaboratory of Stem Cells, Institute of Cell Biology, College of Life Sciences, Zhejiang University, Zhejiang, 310058, Hangzhou, China.
Weibin DuDepartment of Orthopedic Surgery, Xiaoshan Traditional Chinese Medical Hospital, Zhejiang, 311200, Hangzhou, China.
Fei LiuDepartment of Chinese Medicine Rehabilitation, Xiushan People's Hospital, Xiushan, Chongqing, 409900, China.
Weifan RenClinical Medical College, Zhejiang Chinese Medical University, Zhejiang, 310053, Hangzhou, China.
Jinfu WangLaboratory of Stem Cells, Institute of Cell Biology, College of Life Sciences, Zhejiang University, Zhejiang, 310058, Hangzhou, China. wjfu@zju.edu.cn.
Renfu QuanClinical Medical College, Zhejiang Chinese Medical University, Zhejiang, 310053, Hangzhou, China. quanrenfu@126.com.
Zhejiang Chinese Medical University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInduced pluripotent stem cells (iPSCs) can generate epithelial stem cells (EpSCs) as seed cells for skin substitutes to repair skin defects. Here, we investigated the effects of a human acellular amniotic membrane (hAAM) combined with iPSC-derived CD200

methodsHuman urinary cells isolated from a healthy donor were reprogrammed into iPSCs and then induced into CD200

resultsThe results showed that CD200

conclusionsThese results indicated that transplantation of a hAAM combined with iPS-derived EpSCs is feasible to reconstruct skin and skin appendages, and may be a substantial reference for iPSC-based therapy for skin defects.

Indexed as

AmnionFeasibility StudiesHumansInduced Pluripotent Stem CellsSkin TransplantationTissue EngineeringCD200+/ITGA6+ epithelial stem cellsHair follicleInduced pluripotent stem cellsSkin defect

Identifiers

PMID31151466
PMCPMC6545005
OpenAlexW2947822228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.