ArticleArthritis research & therapy2019
Gout, flares, and allopurinol use: a population-based study.
Article in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07061587 (Developing A Gout Action Plan in Primary Care Setting in Singapore), which is not on this map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developing A Gout Action Plan in Primary Care Setting in Singapore
Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Evaluation of measurement properties of the Health Assessment Questionnaire-Disability Index (HAQ-DI) among gout patients in China.Health and quality of life outcomes · 2025Article
- Advances in Understanding the Mechanisms of Treatment for Gouty Arthritis: A Comprehensive Review.Physiological research · 2025Review
- Guideline adherence of xanthine oxidase inhibitor utilization to treat gout in primary care.Journal of managed care & specialty pharmacy · 2025Article
- Firsekibart versus compound betamethasone in acute gout patients unsuitable for standard therapy: A randomized phase 3 trial.Innovation (Cambridge (Mass.)) · 2025Article
- Group-based trajectory modeling to assess adherence to chronic urate-lowering therapies among commercially insured US adults with gout.Journal of managed care & specialty pharmacy · 2025Article
- An observational study of ultrasound semiquantitative scoring for predicting the risk of gout flare.Zeitschrift fur Rheumatologie · 2024Observational
- High vegetable consumption and regular exercise are associated with better quality of life in patients with gout.The Korean journal of internal medicine · 2024Article
- Cohort study investigating gout flares and management in UK general practice.BMC primary care · 2023Article
- Reliability and Validity of the Korean Version of the Gout Impact Scale.Journal of Korean medical science · 2023Article
- Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care.Rheumatology (Oxford, England) · 2023Article
- Hepatic Safety of Febuxostat and Allopurinol for Gout Patients: A Systematic Review of Randomized Controlled Trial.Therapeutics and clinical risk management · 2023Review
- Epidemiology and risk factors associated with gout control among adult Asians: a real-world retrospective cohort study.Frontiers in medicine · 2023Article
- A glance into the future of gout.Therapeutic advances in musculoskeletal disease · 2022Review
- Association of urate deposition shown by ultrasound and frequent gout attacks.Zeitschrift fur Rheumatologie · 2021Article
- Dietary and Lifestyle-Centered Approach in Gout Care and Prevention.Current rheumatology reports · 2021Review
- Serum CA72-4 is specifically elevated in gout patients and predicts flares.Rheumatology (Oxford, England) · 2020Article
- [What is new on gout? : Report from ACR 2018].Zeitschrift fur Rheumatologie · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a paucity of community-based data regarding the prevalence and impact of gout flares as these may often be self-managed. The aim of this study was to determine the prevalence of self-reported gout and gout flares, the use of urate-lowering therapy (ULT), and the association of gout flares with health-related quality of life (HRQoL) in a large community sample. Covariate associations with flare frequency and allopurinol use were also examined.
methodsThe South Australian Health Omnibus Survey is an annual, face-to-face population-based survey. Data collected in the 2017 survey included self-reported medically diagnosed gout, allopurinol use (first-line ULT in Australia), and gout attacks (flares) in the last 12 months, in addition to sociodemographic variables and health-related quality of life (HRQoL, SF-12). Data were weighted to the Australian Bureau of Statistics 2016 census data to reflect the South Australian population. Participants 25 years and over (n = 2778) were included in the analysis.
resultsThe prevalence of gout was 6.5% (95%CI 5.5, 7.5). Amongst participants with gout, 37.1% (95%CI 29.6, 45.3) reported currently using allopurinol, while 23.2% (95%CI 16.9, 21.0) reported prior use (38% discontinuation rate). Frequent flares (≥ 2 in the last year) were reported by 25% of participants with gout and were more likely with younger age, higher body mass index, and current allopurinol use (p < 0.05). The frequency of gout flares was associated with a lower physical HRQoL (p = 0.012). Current allopurinol use was reported by 51% of participants with frequent gout flares.
conclusionFlares were frequently reported by people with gout in the community. Gout flares were associated with reduced physical HRQoL. Almost one half of people with frequent gout flares were not receiving allopurinol, and current allopurinol use was associated with frequent gout flares, suggesting undertreated disease and suboptimal use of ULT. Determining covariate associations with flares and ineffective allopurinol use may identify means of improving treatment and reducing flares.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.