Evidence map›Paper›PMID 31151455›Full record

ArticleMicrobial cell factories2019

Co-production of farnesol and coenzyme Q

Xueduan Chen, Xianzhang Jiang, Man Xu, Mingliang Zhang, Runye Huang, Jianzhong Huang, Feng Qi

Open access · goldAbstract read
In one paragraph

Article in Microbial cell factories, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Improving CoQMicrobial cell factories · 2021
    Article
  5. Article
  6. Article
  7. Review
  8. Coenzyme QFrontiers in bioengineering and biotechnology · 2021
    Article
  9. Article
  10. Enhancement of NADPH availability for coproduction of coenzyme QJournal of industrial microbiology & biotechnology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xueduan ChenEngineering Research Center of Industrial Microbiology of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, Fujian, China.
Xianzhang JiangEngineering Research Center of Industrial Microbiology of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, Fujian, China.
Man XuEngineering Research Center of Industrial Microbiology of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, Fujian, China.
Mingliang ZhangEngineering Research Center of Industrial Microbiology of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, Fujian, China.
Runye HuangEngineering Research Center of Industrial Microbiology of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, Fujian, China.
Jianzhong HuangEngineering Research Center of Industrial Microbiology of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, Fujian, China. hjz@fjnu.edu.cn.
Feng QiEngineering Research Center of Industrial Microbiology of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, Fujian, China. f.qi@fjnu.edu.cn.ORCID http://orcid.org/0000-0001-6349-179X
Fujian Normal University · CN

Funding

National Natural Science Foundation of China 21406130National Natural Science Foundation of China 31741002
6 · The paper itself

Abstract

backgroundFarnesol is an acyclic sesquiterpene alcohol present in the essential oils of various plants in nature. It has been reported to be valuable in medical applications, such as alleviation of allergic asthma, gliosis, and edema as well as anti-cancerous and anti-inflammatory effects. Coenzyme Q

resultsFOH production was significantly increased by overexpressing exogenous terpene synthase (TPS), phosphatidylglycerophosphatase B (PgpB), and sesquiterpene synthase (ATPS), as well as RNAi-mediated silencing of psy coding phytoene synthase (PSY) in R. sphaeroides strains. Rs-TPS, Rs-ATPS, and Rs-PgpB respectively produced 68.2%, 43.4%, and 21.9% higher FOH titers than that of the control strain. Interestingly, the CoQ

conclusionsThe original flux that contributed to phytoene synthesis was effectively redirected to provide precursors toward FOH or CoQ

Indexed as

Alkyl and Aryl TransferasesBiosynthetic PathwaysCarotenoidsEscherichia coliEscherichia coli ProteinsFarnesolGeranylgeranyl-Diphosphate GeranylgeranyltransferaseMetabolic EngineeringPhosphatidate PhosphataseRhodobacter sphaeroidesRNA InterferenceUbiquinoneAlkyl and Aryl Transferases(all-E) phytoeneCarotenoidscoenzyme Q10Escherichia coli ProteinsFarnesolGeranylgeranyl-Diphosphate GeranylgeranyltransferasePgpB protein, E coliPhosphatidate Phosphataseterpene synthaseUbiquinoneCarbon fluxCoQ10FarnesolPSYRNAi

Identifiers

PMID31151455
PMCPMC6544981
OpenAlexW2947013509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.