Evidence map›Paper›PMID 31151430›Full record

ArticleBMC neurology2019

Early identification of peripheral neuropathy based on sudomotor dysfunction in Mexican patients with type 2 diabetes.

Angelica Carbajal-Ramírez, Julián A Hernández-Domínguez, Mario A Molina-Ayala, María Magdalena Rojas-Uribe, Adolfo Chávez-Negrete

Open access · goldAbstract read
In one paragraph

Article in BMC neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. SudoscanJournal of diabetes and metabolic disorders · 2025
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  14. Validation of the Body ScanFrontiers in neurology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Angelica Carbajal-RamírezCentro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtemoc 330, 06720, Mexico City, Mexico. angyc@prodigy.net.mx.
Julián A Hernández-DomínguezMexican Social Security Institute, Mexico City, Mexico.
Mario A Molina-AyalaNational Mexican Social Security Institute, Mexico City, Mexico.
María Magdalena Rojas-UribeMexican Social Security Institute, Mexico City, Mexico.
Adolfo Chávez-NegreteNational Mexican Social Security Institute, Mexico City, Mexico.
Mexican Social Security Institute · MXCentro Medico Nacional Siglo XXI · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 Diabetes in Mexico has a high prevalence, 16-87% of patients may experience peripheral neuropathy. Early detection can prevent or halt its progression. The performance of Sudoscan in detecting neuropathy was compared to the Michigan Neuropathy Screening Instrument (MNSI). The aim was to identificate small fibers neuropathy.

methodsPatients type 2 diabetes received both MNSI and sudomotor function assessment through measurement of electrochemical skin conductance (ESC) in the hands and feet.

resultsTwo hundred twenty-one patients with neuropathy according to MNSI B had lower hands and feet ESC, regardless of diabetes duration. Among the 170 patients who had had diabetes for at least 5 years, 76 of them with normal MNSI B had abnormal hands or feet ESC; this was also the case in 28 out of 51 patients with diabetes than 5 or more years. In contrast, only 5 patients in the first group and 1 in the second group had abnormal MNSI B with normal ESC. Using MNSI B as a reference, abnormal hands or feet ESC (< 60 μS and 70 μS respectively) had a sensitivity of 97%, positive predictive value of 87% to detect neuropathy in patients with longer diabetes duration. The group with shorter diabetes duration, the sensitivity of abnormal hands or feet ESC to detect neuropathy was 91% while the positive predictive value was 88%.

conclusionsThe Sudoscan device, which does not require any preparation, is noninvasive, easy and rapid to perform, can be useful in the early diagnosis peripheral neuropathy in type 2 diabetic.

Indexed as

Galvanic Skin ResponseAgedDiabetes Mellitus, Type 2Diabetic NeuropathiesFemaleHumansMaleMexicoMiddle AgedNeurologic ExaminationSurveys and QuestionnairesDiabetic neuropathyElectrochemical skin conductancesMNSISmall fiber neuropathies

Identifiers

PMID31151430
PMCPMC6544976
OpenAlexW2946921982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.