Evidence map›Paper›PMID 31151322›Full record

ArticleInternational journal of molecular sciences2019

Artemisinin Attenuated Hydrogen Peroxide (H

Xia Zhao, Jiankang Fang, Shuai Li, Uma Gaur, Xingan Xing, Huan Wang, Wenhua Zheng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Annexin A5 ameliorates HMolecular biology reports · 2025
    Article
  8. A morphology and secretome map of pyroptosis.Molecular biology of the cell · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Protective Effect of Arzanol against HInternational journal of molecular sciences · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xia ZhaoCenter of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China. yb77625@um.edu.mo.
Jiankang FangCenter of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China. yb57646@um.edu.mo.
Shuai LiCenter of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China. yb67619@um.edu.mo.
Uma GaurCenter of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China. gaur.uma2906@gmail.com.
Xingan XingCenter of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China. yb77638@um.edu.mo.
Huan WangCenter of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China. yb77624@um.edu.mo.
Wenhua ZhengCenter of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China. wenhuazheng@umac.mo.
University of Macau · MO

Funding

National Natural Science Foundation of China 31771128Science and Technology Development Fund (FDCT) of Macao 016/2016/A1University of Macau MYRG2016-00052-FHS and MYRG2018-00134-FHS
6 · The paper itself

Abstract

Oxidative stress is believed to be one of the main causes of neurodegenerative diseases such as Alzheimer's disease (AD). The pathogenesis of AD is still not elucidated clearly but oxidative stress is one of the key hypotheses. Here, we found that artemisinin, an anti-malarial Chinese medicine, possesses neuroprotective effects. However, the antioxidative effects of artemisinin remain to be explored. In this study, we found that artemisinin rescued SH-SY5Y and hippocampal neuronal cells from hydrogen peroxide (H

Indexed as

AMP-Activated Protein KinasesAnimalsAntimalarialsApoptosisArtemisininsCell Line, TumorCells, CulturedHippocampusHumansHydrogen PeroxideMembrane Potential, MitochondrialMice, Inbred C57BLNeuronsNeuroprotective AgentsOxidative StressReactive Oxygen SpeciesAMP-Activated Protein KinasesAntimalarialsartemisininArtemisininsHydrogen PeroxideNeuroprotective AgentsReactive Oxygen SpeciesAMPK pathwayartemisininH2O2hippocampal neuronsSH-SY5Y cells

Identifiers

PMID31151322
PMCPMC6600327
OpenAlexW2946838850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.