ArticlePolymers2019
Biocompatible Materials Based on Plasticized Poly(lactic acid), Chitosan and Rosemary Ethanolic Extract I. Effect of Chitosan on the Properties of Plasticized Poly(lactic acid) Materials.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed.
- Recent Insights into the Research of (Bio)Active Additives for Advanced Polymer Materials.Polymers · 2025Review
- Emerging Trends in Active Packaging for Food: A Six-Year Review.Foods (Basel, Switzerland) · 2025Review
- Harnessing the Potential of Natural Composites in Biomedical 3D Printing.Materials (Basel, Switzerland) · 2024Review
- Article
- Determination of Biogenic Amine Level Variations upon Storage, in Chicken Breast Coated with Edible Protective Film.Foods (Basel, Switzerland) · 2024Article
- Properties of active packaging of PLA-PCL film integrated with chitosan as an antibacterial agent andHeliyon · 2024Article
- Characterization and modeling of diffusion kinetics of rosemary oleoresin extract from gellan gum-based film.Journal of food science and technology · 2023Article
- Self-Assembled Amphiphilic Chitosan Nanomicelles: Synthesis, Characterization and Antibacterial Activity.Biomolecules · 2023Article
- Additive Manufacturing and Mechanical Characterization of PLA-Based Skull Surrogates.Polymers · 2022Article
- Investigation on Some Algal Extracts as Appropriate Stabilizers for Radiation-Processed Polymers.Polymers · 2022Article
- Effect of maleic anhydride grafted poly(lactic acid) on rheological behaviors and mechanical performance of poly(lactic acid)/poly(ethylene glycol) (PLA/PEG) blends.RSC advances · 2022Article
- Application of Fungal Biomass for the Development of New Polylactic Acid-Based Biocomposites.Polymers · 2022Article
- Effect of Gamma Irradiation on the PLA-Based Blends and Biocomposites Containing Rosemary Ethanolic Extract and Chitosan.Polymers · 2022Article
- Susceptibility-weighted imaging at high-performance 0.5T magnetic resonance imaging system: Protocol considerations and experimental results.Frontiers in neuroscience · 2022Article
- Polylactide Films with the Addition of Olive Leaf Extract-Physico-Chemical Characterization.Materials (Basel, Switzerland) · 2021Article
- Active PLA Packaging Films: Effect of Processing and the Addition of Natural Antimicrobials and Antioxidants on Physical Properties, Release Kinetics, and Compostability.Antioxidants (Basel, Switzerland) · 2021Review
- Encapsulation of Natural Bioactive Compounds by Electrospinning-Applications in Food Storage and Safety.Polymers · 2021Review
- Bioactive Electrospun Fibers of Poly(ε-Caprolactone) Incorporating α-Tocopherol for Food Packaging Applications.Molecules (Basel, Switzerland) · 2021Article
- Towards a Bioactive Food Packaging: Poly(Lactic Acid) Surface Functionalized by Chitosan Coating Embedding Clove and Argan Oils.Molecules (Basel, Switzerland) · 2021Article
- Assessment of the In Vivo Release and Biocompatibility of Novel Vesicles Containing Zinc in Rats.Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The purpose of the present study is to develop new multifunctional environmentally friendly materials having applications both in medical and food packaging fields. New poly(lactic acid) (PLA)-based multifunctional materials containing additives derived from natural resources like chitosan (CS) and rosemary extract (R) were obtained by melt mixing. Each of the selected components has its own specific properties such as: PLA is a biodegradable thermoplastic aliphatic polyester derived from renewable biomass, heat-resistant, with mechanical properties close to those of polystyrene and polyethylene terephthalate, and CS offers good antimicrobial activity and biological functions, while R significantly improves antioxidative action necessary in all applications. A synergy of their combination, an optimum choice of their ratio, and processing parameters led to high performance antimicrobial/antioxidant/biocompatible/environmentally degradable materials. The polyethylene glycol (PEG)-plasticized PLA/chitosan/powdered rosemary extract biocomposites of various compositions were characterized in respect to their mechanical and rheological properties, structure by spectroscopy, antioxidant and antimicrobial activities, and in vitro and in vivo biocompatibility. Scanning electron microscopy images evidence the morphology features added by rosemary powder presence in polymeric materials. Incorporation of additives improved elongation at break, antibacterial and antioxidant activity and also biocompatibility. Migration of bioactive components into D1 simulant is slower for PEG-plasticized PLA containing 6 wt % chitosan and 0.5 wt % rosemary extract (PLA/PEG/6CS/0.5 R) biocomposite and it occurred by a diffusion-controlled mechanism. The biocomposites show high hydrophilicity and good in vitro and in vivo biocompatibility. No hematological, biochemical and immunological modifications are induced by subcutaneous implantation of biocomposites. All characteristics of the PEG-plasticized PLA-based biocomposites recommend them as valuable materials for biomedical implants, and as well as for the design of innovative drug delivery systems. Also, the developed biocomposites could be a potential nature-derived active packaging with controlled release of antimicrobial/antioxidant compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.