Evidence map›Paper›PMID 31151248›Full record

ReviewViruses2019

Norovirus Attachment and Entry.

Vincent R Graziano, Jin Wei, Craig B Wilen

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 73 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Impaired K48-polyubiquitination downmodulates mouse norovirus propagation.Frontiers in cellular and infection microbiology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Kaempferol: A Review of Current Evidence of Its Antiviral Potential.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Assignment of Ala, Ile, LeuBiomolecular NMR assignments · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vincent R GrazianoDepartments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. vincent.graziano@yale.edu.
Jin WeiDepartments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Jin.wei@yale.edu.
Craig B WilenDepartments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. craig.wilen@yale.edu.ORCID 0000-0003-2495-9403
Yale University · US

Funding

Role of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoK08AI128043 · NIAID · YALE UNIVERSITY · PI WILEN, CRAIG BRIAN · 2017 to 2021
$940k
NIAID NIH HHS K08 AI128043NIH HHS K08 AI128043
6 · The paper itself

Abstract

Human norovirus is a major human pathogen causing the majority of cases of viral gastroenteritis globally. Viral entry is the first step of the viral life cycle and is a significant determinant of cell tropism, host range, immune interactions, and pathogenesis. Bile salts and histo-blood group antigens are key mediators of norovirus entry; however, the molecular mechanisms by which these molecules promote infection and the identity of a potential human norovirus receptor remain unknown. Recently, there have been several important advances in norovirus entry biology including the identification of CD300lf as the receptor for murine norovirus and of the role of the minor capsid protein VP2 in viral genome release. Here, we will review the current understanding about norovirus attachment and entry and highlight important future directions.

Indexed as

Viral TropismVirus AttachmentVirus InternalizationAnimalsBlood Group AntigensCaliciviridae InfectionsCapsid ProteinsGenome, ViralHost SpecificityHumansMiceNorovirusReceptors, ImmunologicReceptors, VirusViral Structural ProteinsBlood Group AntigensCapsid ProteinsCLM-1 protein, mouseReceptors, ImmunologicReceptors, VirusViral Structural Proteinsbile saltsCD300lfhisto-blood group antigensJAM-Amurine norovirusnorovirus entryviral tropism

Identifiers

PMID31151248
PMCPMC6630345
OpenAlexW2947535244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.