Evidence map›Paper›PMID 31151223›Full record

ReviewCancers2019

In-Vivo and Ex-Vivo Tissue Analysis through Hyperspectral Imaging Techniques: Revealing the Invisible Features of Cancer.

Martin Halicek, Himar Fabelo, Samuel Ortega, Gustavo M Callico, Baowei Fei

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07036783 (Multimodal Data Collection for the Development and Validation of the STRATUM Tool to Assist Surgery in Patients Affected by Brain Tumours), which is not on this map. Cited by 97 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 3 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07036783 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Multimodal Data Collection for the Development and Validation of the STRATUM Tool to Assist Surgery in Patients Affected by Brain Tumours: Observational Study

Typeobservational_patient_registrySponsorFundación Canaria Instituto de Investigación Sanitaria de CanariasRan2025 to 2027Enrolled320ConditionsBrain (Nervous System) Cancers, Brain Tumor, Primary
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 3 syntheses or guidelines pooled it, 231 citations in OpenAlex.

  1. Pooled it
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  8. Artificial intelligence in respiratory medicine: From diagnosis to treatment and future directions.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  9. Article
  10. Neural illumination calibration for surgical workflow-optimized spectral imaging.International journal of computer assisted radiology and surgery · 2026
    Article
  11. Article
  12. Article
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  18. Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Martin HalicekDepartment of Bioengineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA. martin.halicek@gatech.edu.
Himar FabeloDepartment of Bioengineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA. hfabelo@iuma.ulpgc.es.ORCID 0000-0002-9794-490X
Samuel OrtegaInstitute for Applied Microelectronics (IUMA), University of Las Palmas de Gran Canaria (ULPGC), 35017 Las Palmas de Gran Canaria, Spain. sortega@iuma.ulpgc.es.ORCID 0000-0002-7519-954X
Gustavo M CallicoInstitute for Applied Microelectronics (IUMA), University of Las Palmas de Gran Canaria (ULPGC), 35017 Las Palmas de Gran Canaria, Spain. gustavo@iuma.ulpgc.es.ORCID 0000-0002-3784-5504
Baowei FeiDepartment of Bioengineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA. bfei@utdallas.edu.
Universidad de Las Palmas de Gran Canaria · ESGeorgia Institute of Technology · USThe University of Texas at Dallas · US

Funding

ACADEMIC-INDUSTRIAL PARTNERSHIP FOR TRANSLATION OF PET/TRUS GUIDED INTERVENTIONR01CA204254 · NCI · UNIVERSITY OF TEXAS DALLAS · PI FEI, BAOWEI · 2017 to 2021
$2.0M
MOLECULAR IMAGING DIRECTED, 3D ULTRASOUND-GUIDED, BIOPSY SYSTEMR01CA156775 · NCI · UNIVERSITY OF TEXAS DALLAS · PI FEI, BAOWEI · 2011 to 2016
$1.7M
Canarian Agency for Research, Innovation and the Information Society ProID2017010164European Commission 618080Foundation for the National Institutes of Health R01CA156775Foundation for the National Institutes of Health R01CA204254Foundation for the National Institutes of Health R01HL140325Foundation for the National Institutes of Health R21CA176684NCI NIH HHS R01 CA156775NCI NIH HHS R01 CA204254
6 · The paper itself

Abstract

In contrast to conventional optical imaging modalities, hyperspectral imaging (HSI) is able to capture much more information from a certain scene, both within and beyond the visual spectral range (from 400 to 700 nm). This imaging modality is based on the principle that each material provides different responses to light reflection, absorption, and scattering across the electromagnetic spectrum. Due to these properties, it is possible to differentiate and identify the different materials/substances presented in a certain scene by their spectral signature. Over the last two decades, HSI has demonstrated potential to become a powerful tool to study and identify several diseases in the medical field, being a non-contact, non-ionizing, and a label-free imaging modality. In this review, the use of HSI as an imaging tool for the analysis and detection of cancer is presented. The basic concepts related to this technology are detailed. The most relevant, state-of-the-art studies that can be found in the literature using HSI for cancer analysis are presented and summarized, both in-vivo and ex-vivo. Lastly, we discuss the current limitations of this technology in the field of cancer detection, together with some insights into possible future steps in the improvement of this technology.

Indexed as

artificial intelligencebiomedical optical imagingcancerclinical diagnosishyperspectral imagingmachine learningmedical diagnostic imaging

Identifiers

PMID31151223
PMCPMC6627361
OpenAlexW2947976683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.