Evidence map›Paper›PMID 31151176›Full record

ArticleMolecules (Basel, Switzerland)2019

New Phenolic Derivatives of Thiazolidine-2,4-dione with Antioxidant and Antiradical Properties: Synthesis, Characterization, In Vitro Evaluation, and Quantum Studies.

Gabriel Marc, Anca Stana, Smaranda Dafina Oniga, Adrian Pîrnău, Laurian Vlase, Ovidiu Oniga

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  11. NovelFood technology and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriel MarcDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. marc.gabriel@umfcluj.ro.ORCID 0000-0001-9397-0388
Anca StanaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. teodora_anca@yahoo.com.ORCID 0000-0002-8453-3642
Smaranda Dafina OnigaDepartment of Therapeutic Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj-Napoca, Romania. smaranda.oniga@umfcluj.ro.ORCID 0000-0002-0297-7697
Adrian PîrnăuNational Institute for Research and Development of Isotopic and Molecular Technologies, RO-400293 Cluj-Napoca, Romania. adrian.pirnau@itim-cj.ro.
Laurian VlaseDepartment of Pharmaceutical Technology and Biopharmaceutics, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. vlaselaur@yahoo.com.
Ovidiu OnigaDepartment of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. onigao65@yahoo.com.

Funding

"Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania PCD 7690/68/15.04.2016, 5200/59/01.03.2017, 3067/4/01.02.2018, 1526/39/18.01.2019Romanian Ministry of Research and Innovation Core Program, PN 19 35 02 01
6 · The paper itself

Abstract

Oxidative stress has been incriminated in the physiopathology of many diseases, such as diabetes, cancer, atherosclerosis, and cardiovascular and neurodegenerative diseases. There is a great interest in developing new antioxidants that could be useful for preventing and treating conditions for which oxidative stress is suggested as the root cause. The thiazolidine-2,4-dione derivatives have been reported to possess various pharmacological activities and the phenol moiety is known as a pharmacophore in many naturally occurring and synthetic antioxidants. Twelve new phenolic derivatives of thiazolidine-2,4-dione were synthesized and physicochemically characterized. The antioxidant capacity of the synthesized compounds was assessed through several in vitro antiradical, electron transfer, and Fe

Indexed as

AntioxidantsChelating AgentsChemistry Techniques, SyntheticElectron TransportFree RadicalsFree Radical ScavengersHumansMolecular StructurePhenolsQuantum TheoryThiazolidinedionesAntioxidantsChelating AgentsFree RadicalsFree Radical ScavengersPhenolsthiazolidine-2,4-dioneThiazolidinedionesantioxidantantiradicalphenolquantum descriptorssalicylamidethiazolidine-2,4-dione

Identifiers

PMID31151176
PMCPMC6600258

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.