ArticleNeuroImage. Clinical2019
Cross-sectional and longitudinal associations between total and regional white matter hyperintensity volume and cognitive and motor function in Parkinson's disease.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- White matter lesions disrupt cholinergic pathways important for cognition in Parkinson's disease.Brain : a journal of neurology · 2026Article
- Comparison of automated white matter lesion segmentation approaches for use in large, multi-site data analyses in Parkinson's disease.Frontiers in neuroscience · 2026Article
- Investigating the impact of white matter hyperintensities on longitudinal progression in progressive supranuclear palsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum.NPJ Parkinson's disease · 2025Article
- Contributions of Cerebral White Matter Hyperintensities to Postural Instability in Aging With and Without Alcohol Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Gray matter loss relates to dual task gait in Lewy body disorders and aging.Journal of neurology · 2024Article
- Regional white matter hyperintensity volume in Parkinson's disease and associations with the motor signs.Annals of clinical and translational neurology · 2023Article
- Assessing the association between white matter lesions and Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Lacunes may worsen cognition but not motor function in Parkinson's disease.Brain and behavior · 2023Article
- Regional white matter hyperintensity volume predicts persistent cognitive impairment in acute lacunar infarct patients.Frontiers in neurology · 2023Article
- White matter hyperintensities burden in the frontal regions is positively correlated to the freezing of gait in Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol.Journal of Alzheimer's disease : JAD · 2023Article
- Higher-resolution quantification of white matter hypointensities by large-scale transfer learning from 2D images on the JPSC-AD cohort.Human brain mapping · 2022Article
- Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Baseline predictors of progression of Parkinson's disease in a sample of Egyptian patients: clinical and biochemical.The Egyptian journal of neurology, psychiatry and neurosurgery · 2022Article
- Correlation Between Lacunae and the Wearing-off Phenomenon in Parkinson's Disease.Neuropsychiatric disease and treatment · 2022Article
- Arterial Blood Pressure Variability and Other Vascular Factors Contribution to the Cognitive Decline in Parkinson's Disease.Molecules (Basel, Switzerland) · 2021Review
- Total Cerebral Small Vessel Score Association With Hoehn and Yahr Stage in Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
- Cognitive and motor correlates of grey and white matter pathology in Parkinson's disease.NeuroImage. Clinical · 2020Article
- Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease.Frontiers in neurology · 2020Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWhite matter hyperintensities (WMH) are frequently observed on T2-weighted brain magnetic resonance imaging studies of healthy older adults and have been linked with impairments in balance, gait, and cognition. Nonetheless, few studies have investigated the longitudinal effects of comorbid WMH on cognition and motor function in Parkinson's disease.
methodsThe Lesion Segmentation Tool for Statistical Parametric Mapping was used to obtain total lesion volume and map regional WMH probabilities in 29 PD and 42 control participants at two study visits 18 months apart. Both cross-sectional and longitudinal comparisons were made between composite scores in the domains of executive function, memory, and language, and Unified Parkinson's Disease Rating Scale (UPDRS) scores.
resultsWe found no difference between disease and control groups in total WMH volume or progression during the study. Greater regional and global WMH at baseline was more strongly associated with lower executive function in PD subjects than in controls. Increased regional WMH was also more strongly associated with impaired memory performance in PD relative to controls. Longitudinally, no associations between cognitive change and total or regional WMH progression were detected in either group. A positive relationship between baseline regional WMH and total UPDRS scores was present in the control group, but not PD. However, greater WMH increase was associated with a greater increase in UPDRS motor sub-scores in PD.
conclusionsThese findings suggest that although PD patients do not experience greater mean WMH load than normal aged adults, comorbid WMH do exacerbate cognitive and motor symptoms in PD.
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