ArticleDiabetes research and clinical practice2019
Isolated HbA1c identifies a different subgroup of individuals with type 2 diabetes compared to fasting or post-challenge glucose in Asian Indians: The CARRS and MASALA studies.
Article in Diabetes research and clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Contributions of 2-h post-load glucose, fasting blood glucose and glycosylated haemoglobin elevations to the prevalence of diabetes and pre-diabetes in adults: A systematic analysis of global data.Diabetes, obesity & metabolism · 2025Pooled it
- Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older.The Lancet. Global health · 2025Article
- Immigration, acculturation, and diabetes: A comparative study of diabetes prevalence among Asian Indian immigrants living in the United States and native-born populations in India and the United States.SSM - population health · 2025Article
- South Asians and cardiometabolic health: A framework for comprehensive care for the individual, community, and population - An American society for preventive cardiology clinical practice statement.American journal of preventive cardiology · 2025Article
- Diabetes and all-cause mortality among middle-aged and older adults in China, England, Mexico, rural South Africa, and the USA: a population-based study of longitudinal aging cohorts.BMJ open diabetes research & care · 2025Article
- The impact of using self-report versus objective measures of cardiometabolic conditions in epidemiologic research: a case study from India using data from the longitudinal aging study in India.Frontiers in epidemiology · 2024Article
- Ethnicity Affects A1C Levels in Patients With Diagnosed Type 2 Diabetes in Southern Israel.Diabetes spectrum : a publication of the American Diabetes Association · 2024Article
- Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c.Nature medicine · 2023Article
- Identification and Management of Atherosclerotic Cardiovascular Disease Risk in South Asian Populations in the U.S.JACC. Advances · 2023Article
- The Effect of Family-Centered Intervention on Key Indicators of Diabetes Management and Control in Patients with Type-2 Diabetes.International journal of preventive medicine · 2023Article
- Article
- Epidemiology of diabetes among South Asians in the United States: lessons from the MASALA study.Annals of the New York Academy of Sciences · 2021Review
- Lifetime risk of diabetes in metropolitan cities in India.Diabetologia · 2021Article
- Incidence of diabetes in South Asian young adults compared to Pima Indians.BMJ open diabetes research & care · 2021Article
- Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Pitfalls of HbA1c in the Diagnosis of Diabetes.The Journal of clinical endocrinology and metabolism · 2020Article
- Review of methods for detecting glycemic disorders.Diabetes research and clinical practice · 2020Review
- Article
- Early Universal Screening with a Combination of Fasting Plasma Glucose and Glycated Haemoglobin is the Best Community Screening Strategy for Dysglycaemia in Indian Youth.Indian journal of endocrinology and metabolismArticle
- Endocrinologists of Indian Origin: A Global Force that can (and should) Collaborate.Indian journal of endocrinology and metabolismArticle
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Authors and funding
13 authors at 8 institutions in 3 countries.
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Abstract
aimsGuidelines recommend hemoglobin A1c (HbA1c) as a diagnostic test for type 2 diabetes, but its accuracy may differ in certain ethnic groups.
methodsThe prevalence of type 2 diabetes by HbA1c, fasting glucose, and 2 h glucose was compared in 3016 participants from Chennai and Delhi, India from the CARRS-2 Study to 757 Indians in the U.S. from the MASALA Study. Type 2 diabetes was defined as fasting glucose ≥ 7.0 mmol/L, 2-h glucose ≥ 11.1 mmol/L, or HbA1c ≥ 6.5%. Isolated HbA1c diabetes was defined as HbA1c ≥ 6.5% with fasting glucose < 7.0 mmol/L and 2 h glucose < 11.1 mmol/L.
resultsThe age, sex, and BMI adjusted prevalence of diabetes by isolated HbA1c was 2.9% (95% CI: 2.2-4.0), 3.1% (95% CI: 2.3-4.1), and 0.8% (95% CI: 0.4-1.8) in CARRS-Chennai, CARRS-Delhi, and MASALA, respectively. The proportion of diabetes diagnosed by isolated HbA1c was 19.4%, 26.8%, and 10.8% in CARRS-Chennai, CARRS-Delhi, and MASALA respectively. In CARRS-2, individuals with type 2 diabetes by isolated HbA1c milder cardio-metabolic risk than those diagnosed by fasting or 2-h measures.
conclusionsIn Asian Indians, the use of HbA1c for type 2 diabetes diagnosis could result in a higher prevalence. HbA1c may identify a subset of individuals with milder glucose intolerance.
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