Evidence map›Paper›PMID 31150638›Full record

ArticleChest2019

Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study.

Matthew Shorofsky, Jean Bourbeau, John Kimoff, Rachel Jen, Atul Malhotra, Najib Ayas, Wan C Tan, Shawn D Aaron, Don D Sin, Jeremy Road and 9 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07311499 (A Study on Improving Sleep Quality in COPD Patients Through Inhalation Management Education by Nurses Using Video Conferencing Tools.), which is not on this map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07311499 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Study on Improving Sleep Quality in COPD Patients Through Inhalation Management Education by Nurses Using Video Conferencing Tools.

TypeinterventionalSponsorKumamoto UniversityRan2026 to 2029Enrolled60ConditionsChronic Obstructive Lung DiseaseArmsinhalation management education
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Impact of positive airway pressure for chronic hypercapnic respiratory failure on sleep quality: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Matthew ShorofskyRespiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.
Jean BourbeauRespiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.
John KimoffRespiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.
Rachel JenDivision of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Atul MalhotraPulmonary and Critical Care, University of California San Diego, San Diego, CA.
Najib AyasDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Wan C TanUniversity of British Columbia, Vancouver, BC, Canada.
Shawn D AaronThe Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Don D SinUniversity of British Columbia Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.
Jeremy RoadUniversity of British Columbia, Vancouver, BC, Canada.
Kenneth R ChapmanAsthma & Airway Centre, University Health Network and University of Toronto, Toronto, ON, Canada.
Denis E O'DonnellDepartment of Medicine/Physiology, Queens University, Kingston, ON, Canada.
François MaltaisInstitut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, QC, Canada.
Paul HernandezFaculty of Medicine, Division of Respirology, Dalhousie University, Halifax, NS, Canada.
Brandie L WalkerUniversity of Calgary, Calgary, AB, Canada.
Darcy MarciniukRespiratory Research Center, University of Saskatchewan, Saskatoon, SK, Canada.
Marta KaminskaRespiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada. Electronic address: marta.kaminska@mcgill.ca.
Canadian Respiratory Research Network
CanCOLD Collaborative Research group

Funding

Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Assessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611k
NHLBI NIH HHS K24 HL132105NHLBI NIH HHS R01 HL085188NHLBI NIH HHS T32 HL134632
6 · The paper itself

Abstract

backgroundCOPD increases susceptibility to sleep disturbances, which may in turn predispose to increased respiratory symptoms. The objective of this study was to evaluate, in a population-based sample, the relationship between subjective sleep quality and risk of COPD exacerbations.

methodsData were obtained from the Canadian Cohort Obstructive Lung Disease (CanCOLD) study. Participants with COPD who had completed 18 months of follow-up were included. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and a three-factor analysis. Symptom-based (dyspnea or sputum change ≥ 48 h) and event-based (symptoms plus medication or unscheduled health services use) exacerbations were assessed. Association of PSQI with exacerbation rate was assessed by using negative binomial regression. Exacerbation-free survival was also assessed.

resultsA total of 480 participants with COPD were studied, including 185 with one or more exacerbations during follow-up and 203 with poor baseline sleep quality (PSQI score > 5). Participants with subsequent symptom-based exacerbations had higher median baseline PSQI scores than those without (6.0 [interquartile range, 3.0-8.0] vs 5.0 [interquartile range, 2.0-7.0]; P = .01), and they were more likely to have baseline PSQI scores > 5 (50.3% vs 37.3%; P = .01). Higher PSQI scores were associated with increased symptom-based exacerbation risk (adjusted rate ratio, 1.09; 95% CI, 1.01-1.18; P = .02) and event-based exacerbation risk (adjusted rate ratio, 1.10; 95% CI, 1.00-1.21; P = .048). The association occurred mainly in those with undiagnosed COPD. Strongest associations were with Factor 3 (sleep disturbances and daytime dysfunction). Time to symptom-based exacerbation was shorter in participants with poor sleep quality (adjusted hazard ratio, 1.49; 95% CI, 1.09-2.03).

conclusionsHigher baseline PSQI scores were associated with increased risk of COPD exacerbation over 18 months' prospective follow-up.

Indexed as

Disease ProgressionSleepAgedCohort StudiesDyspneaFemaleHealth ServicesHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesPulmonary Disease, Chronic ObstructiveSleep Wake DisordersSputumTime Factorsacute exacerbation of chronic bronchitisCOPDsleep medicine

Identifiers

PMID31150638
PMCPMC6945650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.