ArticleCell2019
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice.
2 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 673 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
673citing papers in PubMed, 8 pooled it
70.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07450443 phase2 / phase3recruitingnot on this mapstarted 2023, after this paper: background citation
Role of the Gut Vascular Barrier and Microbiota in Autism Spectrum Disorders: Evaluation of Efficacy of Postbiotic-based Nutraceutical Treatment
NCT07546942 phase1 / phase2enrolling by invitationnot on this mapstarted 2026, after this paper: background citation
Autism Spectral Disorder (ASD) In Adolescent-Adults Treated by Multimodal Protocol: IV Autologous cSVF, Interval IV Autologous MSCs (Cryopreserved), Strick Ketogenic Diet RESET Program, and Fecal Microbiota Transplantation (FMT)
Who cites it
673 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,138 citations in OpenAlex.
- Efficacy of pharmacological and microbiota-based therapies in preclinical models of autism spectrum disorder: a systematic review.Molecular psychiatry · 2026Pooled it
- Fecal microbiota transplantation from psychiatric patients to mice - systematic review of methodologies and a call for standardization.Translational psychiatry · 2026Pooled it
- Bibliometric analysis of human microbiota-associated animal model (2005-2025).Frontiers in microbiology · 2026Pooled it
- Global trends and future perspectives in autism spectrum disorder and gut microbiota research: a comprehensive bibliometric analysis.Frontiers in neuroscience · 2026Pooled it
- The effects of social story interventions on individuals with Autism Spectrum Disorders and influencing factors: a meta-analysis of single-case experimental studies.Frontiers in psychology · 2026Pooled it
- Microbial dysbiosis as a diagnostic marker in psychiatric disorders: a systematic review of gut-brain axis disruptions.Frontiers in neuroscience · 2026Pooled it
- Neurodevelopmental Outcomes Associated with Early-Life Exposure to Heavy Metals: A Systematic Review.International journal of environmental research and public health · 2025Pooled it
- Microbiota-based interventions for autism spectrum disorder: a systematic review of efficacy and clinical potential.Frontiers in microbiology · 2025Pooled it
- Rifaximin Plus Probiotics Reshape Gut Microbiota, Serum Propionate, and Mucosal Immunity in Cirrhosis-Related Hepatic Encephalopathy Microbiota-Immune Remodeling in HE.Canadian journal of gastroenterology & hepatology · 2026Trial
- Gut microbiota remodeling and sensory-emotional functional disruption in adolescents with bipolar depression.Journal of translational medicine · 2025Trial
- Nutritional regulation of gut-brain immune crosstalk across the lifespan.Gut microbes · 2026Review
- Article
- Mapping the knowledge structure and emerging trends of blood-based biomarkers in autism spectrum disorder: A bibliometric analysis (2016-2026).IBRO neuroscience reports · 2026Article
- Functional Heterogeneity of the Autism Spectrum Disorder-Associated Gut Microbial Ecosystem Revealed by Fecal Lipopolysaccharides and Bacterial Proteomic Profiling.Chembiochem : a European journal of chemical biology · 2026Article
- Oral Actinomyces Species Exposure is Associated with Anxiety-Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Review
- Research Progress on Bidirectional Regulation of the Microbiota-Gut-Brain Axis in Autism Spectrum Disorder Based on the Immune-Metabolic-Endocrine Interactive Network.Biomolecules · 2026Review
- Gut microbiota-derived 5-HTP penetrates the host blood-brain barrier and ameliorates autism symptoms.Acta pharmaceutica Sinica. B · 2026Article
- ADAM10's combined influence on the diagnostic usefulness of IL 22, IL 10, IL-17 A, and IL-17D in autism spectrum disorders: Predicted role on gut leakiness as co-morbidity.Metabolic brain disease · 2026Article
613 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 8 institutions in 2 countries.
Gil SharonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: gsharon@caltech.edu.
Nikki Jamie CruzDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Dae-Wook KangBiodesign Swette Center for Environmental Biotechnology, Arizona State University, Tempe, AZ 85287, USA; Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ 85287, USA.
Michael J GandalCenter for Autism Research and Treatment, Program in Neurobehavioral Genetics, Semel Institute, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Neurology, Semel Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Bo WangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Young-Mo KimEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Erika M ZinkEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Cameron P CaseyEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Bryn C TaylorBiomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
Christianne J LaneDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Lisa M BramerNational Security Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Nancy G IsernEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
David W HoytEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Cecilia NoeckerDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Michael J SweredoskiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Annie MoradianDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Elhanan BorensteinDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Department of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA; Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 6997801, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel; Santa Fe Institute, Santa Fe, NM 87501, USA.
Janet K JanssonEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Rob KnightCenter for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Biongineering, University of California, San Diego, La Jolla, CA 92093, USA.
Thomas O MetzEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Carlos LoisDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Daniel H GeschwindCenter for Autism Research and Treatment, Program in Neurobehavioral Genetics, Semel Institute, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Neurology, Semel Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Rosa Krajmalnik-BrownBiodesign Swette Center for Environmental Biotechnology, Arizona State University, Tempe, AZ 85287, USA; Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ 85287, USA; School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85287, USA.
Sarkis K MazmanianDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: sarkis@caltech.edu.
Pacific Northwest National Laboratory · USCalifornia Institute of Technology · USArizona State University · USUniversity of California, Los Angeles · USUniversity of California San Diego · USSanta Fe Institute · USUniversity of Southern California · USUniversity of Washington · US
Funding
Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 2007 to 2021
$32.0MAutism Genetics, Phase II: Increasing Representation of Human DiversityR01MH100027 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2013 to 2024
$31.7M1/2 Genomic Strategies to Identify High-impact Psychiatric Risk VariantsU01MH105578 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B., GESCHWIND, DANIEL H · 2014 to 2018
$8.5Mthe self-tuning brain: cellular and circuit mechanisms of behavioral resilienceR01NS104925 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI FAIRHALL, ADRIENNE L, GARDNER, TIMOTHY JAMES · 2017 to 2022
$5.4MInvestigating the Gut Microbiome for Novel Therapies and Diagnostics for AutismR01MH100556 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MAZMANIAN, SARKIS K · 2013 to 2017
$2.8MMetabolic model-based integrative study of the relationship between the gut microbiome, metabolome, and dietR01GM124312 · NIGMS · UNIVERSITY OF WASHINGTON · PI BORENSTEIN, ELHANAN · 2017 to 2018
$593kAutism Speaks AS9718NICHD NIH HHS P50 HD055784NIGMS NIH HHS R01 GM124312NIMH NIH HHS R01 MH100027NIMH NIH HHS R01 MH100556NIMH NIH HHS U01 MH105578NINDS NIH HHS R01 NS104925
Abstract
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically developing (TD) and ASD individuals, though it remains unclear whether the microbiome contributes to symptoms. We transplanted gut microbiota from human donors with ASD or TD controls into germ-free mice and reveal that colonization with ASD microbiota is sufficient to induce hallmark autistic behaviors. The brains of mice colonized with ASD microbiota display alternative splicing of ASD-relevant genes. Microbiome and metabolome profiles of mice harboring human microbiota predict that specific bacterial taxa and their metabolites modulate ASD behaviors. Indeed, treatment of an ASD mouse model with candidate microbial metabolites improves behavioral abnormalities and modulates neuronal excitability in the brain. We propose that the gut microbiota regulates behaviors in mice via production of neuroactive metabolites, suggesting that gut-brain connections contribute to the pathophysiology of ASD.
Indexed as
AnimalsAutism Spectrum DisorderBacteriaBehavioral SymptomsBehavior, AnimalBrainDisease Models, AnimalGastrointestinal MicrobiomeHumansMiceMicrobiotaRisk Factorsautismautism spectrum disorderbacterial metabolitesgut-brain axisgut microbiomemetabolomemicrobiotamouse model
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT07450443ClinicalTrials.gov
NCT07546942ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.