ReviewSchizophrenia bulletin2019
The Fragile Brain: Stress Vulnerability, Negative Affect and GABAergic Neurocircuits in Psychosis.
Review in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Going Back to Kahlbaum's Psychomotor (and GABAergic) Origins: Is Catatonia More Than Just a Motor and Dopaminergic Syndrome?Schizophrenia bulletin · 2020Pooled it
- Yoga-Based Group Intervention for Inpatients with Schizophrenia Spectrum Disorders-Feasibility, Acceptability, and Preliminary Outcomes of a Rater-Blinded Randomized Controlled Trial.Schizophrenia bulletin · 2026Trial
- Life events and their subjective appraisal by children and adolescents in clinical high-risk states of psychosis: a cross-sectional comparison with inpatients with non-psychotic disorders and community subjects.European child & adolescent psychiatry · 2026Article
- A Longitudinal Assessment of Anterior Cingulate Cortex Gamma-aminobutyric Acid in Antipsychotic Medication-naïve First Episode Psychosis Patients.Schizophrenia bulletin · 2026Article
- Thoughts Falling Apart: Disorganized Schizotypy Specifically Predicts Both Psychotic- and Stress-Reactivity in Daily Life.Journal of personality · 2026Article
- Exploring the interplay among smoking, stress, and negative affect in patients with psychosis: An experience sampling method study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Response Monitoring Theta-Band Activities Across Emotional Contexts in Schizophrenia and Bipolar Spectrum Disorders.Biological psychiatry global open science · 2025Article
- Stress sensitivity, negative affect, and functioning in an early psychosis clinic.Schizophrenia research · 2025Article
- Biased Information Routing Through the Basolateral Amygdala, Altered Valence Processing, and Impaired Affective States Associated With Psychiatric Illnesses.Biological psychiatry · 2025Review
- Relationship Between Schizotypal Traits, Emotion Regulation, and Negative Affect in Children: A Network Analysis.Schizophrenia bulletin · 2025Article
- Brain metabolic profiling of schizophrenia: a path towards a better understanding of the neuropathogenesis of psychosis.Metabolic brain disease · 2024Review
- Catatonia.Nature reviews. Disease primers · 2024Review
- Interaction between Oligodendrocytes and Interneurons in Brain Development and Related Neuropsychiatric Disorders.International journal of molecular sciences · 2024Review
- Modelling the overlap and divergence of autistic and schizotypal traits on hippocampal subfield volumes and regional cerebral blood flow.Molecular psychiatry · 2024Article
- Application of hyperalignment to resting state data in individuals with psychosis reveals systematic changes in functional networks and identifies distinct clinical subgroups.Aperture neuro · 2024Article
- A Holistic Approach to Cardiopulmonary Concerns in a Schizophrenic Patient and Ensuring Quality Care.Cureus · 2023Article
- The role of negative affects as mediators in the relationship between stress and mental health in Ecuadorian adolescents.Health psychology report · 2023Article
- Association of adverse childhood experiences and cortical neurite density alterations with posttraumatic stress disorder symptoms in autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Recent advancements in biomarker research in schizophrenia: mapping the road from bench to bedside.Metabolic brain disease · 2022Review
- FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus.Journal of neuroinflammation · 2022Article
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4 authors.
Funding
Abstract
Persons with schizophrenia exhibit sensitivity to stress and negative affect (NA), both strongly correlated with poor functional outcome. This theoretical review suggests that NA reflects a "fragile brain," ie, vulnerable to stress, including events not experienced as stressful by healthy individuals. Based on postmortem evidence of altered gamma-aminobutyric acid (GABA) function in parvalbumin positive interneurons (PVI), animal models of PVI abnormalities and neuroimaging data with GABAergic challenge, it is suggested that GABAergic disruptions weaken cortical regions, which leads to stress vulnerability and excessive NA. Neurocircuits that respond to stressful and salient environmental stimuli, such as the hypothalamic-pituitary-adrenal axis and the amygdala, are highly dysregulated in schizophrenia, exhibiting hypo- and hyper-activity. PVI abnormalities in lateral prefrontal cortex and hippocampus have been hypothesized to affect cognitive function and positive symptoms, respectively; in the medial frontal cortex (dorsal anterior cingulate cortex and dorsal medial prefrontal cortex), these abnormalities may lead to vulnerability to stress, NA and dysregulation of stress responsive systems. Given that postmortem PVI disruptions have been identified in other conditions, such as bipolar disorder and autism, stress vulnerability may reflect a transdiagnostic dimension of psychopathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.