ArticlePloS one2019
Patterns of diuretic use in the intensive care unit.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Predicting acute kidney injury in adults after cardiac surgery with a novel clinical metric: The cardiac diuretic-responsiveness index.JTCVS open · 2026Article
- Clinical Pharmacology of Loop Diuretics in Critical Care.Clinical pharmacokinetics · 2025Review
- Association of Sociodemographic Factors With Overtriage, Undertriage, and Value of Care After Major Surgery.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Effects of furosemide, acetazolamide and amiloride on renal cortical and medullary tissue oxygenation in non-anaesthetised healthy sheep.Experimental physiology · 2024Article
- Prognostic Performance of Sequential Organ Failure Assessment, Acute Physiology and Chronic Health Evaluation III, and Simplified Acute Physiology Score II Scores in Patients with Suspected Infection According to Intensive Care Unit Type.Journal of clinical medicine · 2023Article
- Diuretics depletion improves cardiac output and ventriculo-arterial coupling in congestive ICU patients during hemodynamic de-escalation.Journal of clinical monitoring and computing · 2023Article
- Administration of Intravenous Furosemide in Patients with Acute Infection: Patient Characteristics and Impact on In-Hospital Outcome.Journal of clinical medicine · 2023Article
- Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.Science advances · 2022Article
- Goal directed fluid removal with furosemide versus placebo in intensive care patients with fluid overload: A trial protocol for a randomised, blinded trial (GODIF trial).Acta anaesthesiologica Scandinavica · 2022Article
- A whole blood microsampling furosemide assay: development, validation and use in a pediatric pharmacokinetic study.Bioanalysis · 2022Article
- Loop diuretics in adult intensive care patients with fluid overload: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis.Annals of intensive care · 2022Review
- Diuretic combinations in critically ill patients with respiratory failure: A systematic review and meta-analysis.World journal of critical care medicine · 2022Article
- Development, validation, and implementation of an UHPLC-MS/MS method for the quantitation of furosemide in infant urine samples.Biomedical chromatography : BMC · 2022Article
- Relationship Between Initial Urine Output and Mortality in Patients Hospitalized in Cardiovascular Intensive Care Units: More Is Not Better.Frontiers in cardiovascular medicine · 2022Article
- New Insights Into Diuretic Use to Treat Congestion in the ICU: Beyond Furosemide.Frontiers in nephrology · 2022Review
- Human albumin solutions in intensive care: A review.Journal of the Intensive Care Society · 2021Review
- Use of diuretics in shock: Temporal trends and clinical impacts in a propensity-matched cohort study.PloS one · 2020Article
- Estimated effects of early diuretic use in critical illness.Critical care explorations · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo inform future outcomes research on diuretics, we sought to describe modern patterns of diuretic use in the intensive care unit (ICU), including diuretic type, combination, and dosing. We also investigated two possible quality improvement targets: furosemide dosing in renal impairment and inclusion of an initial bolus with continuous furosemide infusions. MATERIALS AND
methodsIn this descriptive study, we retrospectively studied 46,037 adult ICU admissions from a publicly available database of patients in an urban, academic medical center.
resultsDiuretics were employed in nearly half (49%, 22,569/46,037) of ICU admissions. Mechanical ventilation, a history of heart failure, and admission to the post-cardiac surgery unit were associated with a higher frequency of diuretic use. Combination use of different diuretic classes was uncommon. Patients with severely impaired kidney function were less likely to receive diuretics. Furosemide was by far the most common diuretic given and the initial intravenous dose was only 20 mg in more than half of ICU admissions. Among patients treated with a continuous infusion, 30% did not receive a bolus on the day of infusion initiation.
conclusionsPatterns of diuretic use varied by patient-specific factors and by ICU type. Diuretic dosing strategies may be suboptimal.
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