ArticlePloS one2019
Surface charge controlled nucleoli selective staining with nanoscale carbon dots.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Carbon dots as a green alternative for preventingEco-Environment & Health · 2025Article
- Applications of carbon dot-mediated cardiomyocyte maturation in regenerative medicine: a review.Nanomedicine (London, England) · 2025Review
- A mammalian model reveals inorganic polyphosphate channeling into the nucleolus and induction of a hyper-condensate state.Cell reports methods · 2024Article
- Identification of nanoparticles as vesicular cargoNanoscale advances · 2023Article
- Intrinsic specificity of plain ammonium citrate carbon dots forMaterials today. Bio · 2022Article
- Intracellular Trafficking of Cationic Carbon Dots in Cancer Cell Lines MCF-7 and HeLa-Time Lapse Microscopy, Concentration-Dependent Uptake, Viability, DNA Damage, and Cell Cycle Profile.International journal of molecular sciences · 2022Article
- Nitrogen-doped carbon dots for wash-free imaging of nucleolus orientation.Mikrochimica acta · 2021Article
- Lighting up Individual Organelles With Fluorescent Carbon Dots.Frontiers in chemistry · 2021Review
- Bioimaging of C2C12 Muscle Myoblasts Using Fluorescent Carbon Quantum Dots Synthesized from Bread.Nanomaterials (Basel, Switzerland) · 2020Article
- Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Organelle selective imaging can reveal structural and functional characters of cells undergoing external stimuli, and is considered critical in revealing biological fundamentals, designing targeted delivery system, and screening potential drugs and therapeutics. This paper describes the nucleoli targeting ability of nanoscale carbon dots (including nanodiamond) that are hydrothermally made with controlled surface charges. The surface charges of carbon dots are controlled in the range of -17.9 to -2.84 mV by changing the molar ratio of two precursors, citric acid (CA) and ethylenediamine (EDA). All carbon dots samples show strong fluorescence under wide excitation wavelength, and samples with both negative and positve charges show strong fluorescent contrast from stained nucleoli. The nucleoli selective imaging of live cell has been confirmed with Hoechst staining and nucleoli specific staining (SYTO RNA-select green), and is explained as surface charge heterogeneity on carbon dots. Carbon dots with both negative and positive charges have better ability to penetrate cell and nucleus membranes, and the charge heterogeneity helps carbon dots to bind preferentially to nucleoli, where the electrostatic environment is favored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.