ArticleAmerican journal of physiology. Heart and circulatory physiology2019
Elevated bone marrow sympathetic drive precedes systemic inflammation in angiotensin II hypertension.
Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Neuroimmune interactions in cardiovascular homeostasis and disease.American journal of physiology. Cell physiology · 2026Review
- Loss of Bone Marrow β1/β2-Adrenergic Receptors Reprograms Host-Microbiota Interactions and Protects Against Diet-Induced Obesity.bioRxiv : the preprint server for biology · 2026Article
- The role of vascular aging, bone marrow and immune system in hypertension.Cell death discovery · 2026Review
- Potential role of the spleen in the development of arterial hypertension in humans.Journal of hypertension · 2026Article
- The probioticGut microbes · 2025Article
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Neuroimmune Interactions and Their Role in Immune Cell Trafficking in Cardiovascular Diseases and Cancer.International journal of molecular sciences · 2025Review
- Bone Marrow Niche in Cardiometabolic Disease: Mechanisms and Therapeutic Potential.Circulation research · 2025Review
- Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat.Physiological genomics · 2023Article
- Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions.Current hypertension reports · 2022Review
- Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory Phenotype in Peripheral Blood Mononuclear Cells and Plasma of Type 2 Diabetes Subjects.International journal of molecular sciences · 2022Article
- Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications.Nature reviews. Cardiology · 2022Review
- Gut Microbiome and Neuroinflammation in Hypertension.Circulation research · 2022Review
- Renal denervation based on experimental rationale.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Review
- Gut-brain-bone marrow axis in hypertension.Current opinion in nephrology and hypertension · 2021Review
- LOX-1 Deletion Attenuates Myocardial Fibrosis in the Aged Mice, Particularly Those With Hypertension.Frontiers in cardiovascular medicine · 2021Article
- Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing IdentifiedHypertension (Dallas, Tex. : 1979) · 2021Article
- Impact of aging and comorbidities on ischemic stroke outcomes in preclinical animal models: A translational perspective.Experimental neurology · 2021Review
- Intestinal barrier dysfunction as a therapeutic target for cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2020Review
- Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve.Current biology : CB · 2020Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Increased sympathetic nervous system activity is a hallmark of hypertension (HTN), and it is implicated in altered immune system responses in its pathophysiology. However, the precise mechanisms of neural-immune interaction in HTN remain elusive. We have previously shown an association between elevated sympathetic drive to the bone marrow (BM) and activated BM immune cells in rodent models of HTN. Moreover, microglial-dependent neuroinflammation is also seen in rodent models of HTN. However, the cause-effect relationship between central and systemic inflammatory responses and the sympathetic drive remains unknown. These observations led us to hypothesize that increase in the femoral BM sympathetic nerve activity (fSNA) initiates a cascade of events leading to increase in blood pressure (BP). Here, we investigated the temporal relationship between the BM sympathetic drive, activation of the central and peripheral immune system, and increase in BP in the events leading to established HTN. The present study demonstrates that central infusion of angiotensin II (ANG II) induces early microglial activation in the paraventricular nucleus of hypothalamus, which preceded increase in the fSNA. In turn, activation of fSNA correlated with the timing of increased production and release of CD4
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