ReviewPlant biotechnology journal2019
Natural rubber biosynthesis in plants, the rubber transferase complex, and metabolic engineering progress and prospects.
Review in Plant biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 202 citations in OpenAlex.
- Laticifer-specific engineering of rubber biosynthesis inBiodesign research · 2026Article
- From Isoprene Units to Polyprenols and Dolichols: 70 Years of Polyisoprenoid Biosynthesis Research.Cell biochemistry and biophysics · 2026Review
- Positive regulatory role of EuWRKY1 in the biosynthesis of Eucommia ulmoides rubber.Functional & integrative genomics · 2026Article
- TkNACs Heterodimerization and Methyl Jasmonate Signaling Synergistically Mediate Root Development inPlants (Basel, Switzerland) · 2026Article
- Metabolomics reveal drought-stress responses in guayule, a semi-arid rubber crop.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Expression profiles of transcription factors and aquaporins suggest putative roles in rubber biosynthesis regulation and drought stress adaptation in guayule.Scientific reports · 2026Article
- The targeted metabolomic profile of laticifers in rubber tree.Journal of integrative plant biology · 2026Article
- Article
- Ethylene-Enhanced Latex Proteome Is Involved in Stimulation of Natural Rubber Production in the Hevea Rubber Tree.Molecular & cellular proteomics : MCP · 2026Article
- Integrated proteomic and phosphoproteomic analysis reveals the MAPK cascade as a key regulator of ethylene-induced latex production in Hevea brasiliensis.Stress biology · 2026Article
- Overexpression of RNA mMolecular horticulture · 2026Article
- Article
- Stage-specific metabolic divergence in flavonoid biosynthesis correlates with embryogenic capacity in rubber tree (Frontiers in plant science · 2026Article
- Simultaneous Knockout of Tk1-SST and Tk1-FFT via CRISPR/Cas9 Enhances the Natural Rubber Accumulation in Taraxacum kok-saghyz.Plant biotechnology journal · 2025Article
- Geranyl Diphosphate Synthases GDS 1 and GDS7 Facilitate Natural Rubber Biosynthesis inPlants (Basel, Switzerland) · 2025Article
- Characterization of Small Rubber Particle Protein 1 promoter from guayule (Parthenium argentatum).BMC research notes · 2025Article
- Rubber biosynthesis drives the biogenesis and development of rubber particles, the rubber-producing organelles.Plant biotechnology journal · 2025Article
- Article
- Genome-wide identification of the regulatory network of mitogen-activated protein kinase signaling cascades gene families in Hevea Brasiliensis.BMC plant biology · 2025Article
- Characterization of cis-polyisoprene produced in Periploca sepium, a novel promising alternative source of natural rubber.Communications biology · 2025Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural rubber (NR) is a nonfungible and valuable biopolymer, used to manufacture ~50 000 rubber products, including tires and medical gloves. Current production of NR is derived entirely from the para rubber tree (Hevea brasiliensis). The increasing demand for NR, coupled with limitations and vulnerability of H. brasiliensis production systems, has induced increasing interest among scientists and companies in potential alternative NR crops. Genetic/metabolic pathway engineering approaches, to generate NR-enriched genotypes of alternative NR plants, are of great importance. However, although our knowledge of rubber biochemistry has significantly advanced, our current understanding of NR biosynthesis, the biosynthetic machinery and the molecular mechanisms involved remains incomplete. Two spatially separated metabolic pathways provide precursors for NR biosynthesis in plants and their genes and enzymes/complexes are quite well understood. In contrast, understanding of the proteins and genes involved in the final step(s)-the synthesis of the high molecular weight rubber polymer itself-is only now beginning to emerge. In this review, we provide a critical evaluation of recent research developments in NR biosynthesis, in vitro reconstitution, and the genetic and metabolic pathway engineering advances intended to improve NR content in plants, including H. brasiliensis, two other prospective alternative rubber crops, namely the rubber dandelion and guayule, and model species, such as lettuce. We describe a new model of the rubber transferase complex, which integrates these developments. In addition, we highlight the current challenges in NR biosynthesis research and future perspectives on metabolic pathway engineering of NR to speed alternative rubber crop commercial development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.