Evidence map›Paper›PMID 31149967›Full record

ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2019

The Effect of Asphyxia Arrest Duration on a Pediatric End-Tidal CO2-Guided Chest Compression Delivery Model.

Jennifer L Hamrick, Justin T Hamrick, Caitlin E O'Brien, Michael Reyes, Polan T Santos, Sophie E Heitmiller, Ewa Kulikowicz, Jennifer K Lee, Sapna R Kudchadkar, Raymond C Koehler and 2 more

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Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jennifer L HamrickDepartment of Anesthesiology, Rady Children's Hospital, San Diego, CA.
Justin T HamrickDepartment of Anesthesiology, Rady Children's Hospital, San Diego, CA.
Caitlin E O'BrienDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Michael ReyesDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Polan T SantosDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Sophie E HeitmillerDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Ewa KulikowiczDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Jennifer K LeeDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Sapna R KudchadkarDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Raymond C KoehlerDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Elizabeth A HuntDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Donald H ShaffnerDepartment of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, MD.

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Therapeutic Strategies for Neonatal Hypoxic-Ischemiic EncephalopathyR01NS060703 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES · 2008 to 2019
$3.9M
Training for Clinician Scientists in Pediatric Critical Cardiopulmonary DiseaseT32HL125239 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BEMBEA, MELANIA MARIA, EVERETT, ALLEN D · 2015 to 2024
$3.0M
Brain Microstructural MRI in a Piglet Model of Hypoxia-IschemiaR01NS107417 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LEE, JENNIFER KIM · 2018 to 2022
$1.8M
Neuronal injury after pediatric cardiac arrest, hypothermia, and rewarmingK08NS080984 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LEE, JENNIFER KIM · 2014 to 2018
$960k
Use of transnasal air flow to cool and protect the brain after pediatric cardiac arrestR21NS095036 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES, TANDRI, HARIKRISHNA · 2016 to 2017
$446k
End-tidal carbon dioxide (ETCO2) directed cardiopulmonary resuscitation (CPR)R21HD072845 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SHAFFNER, DONALD H · 2014 to 2015
$440k
NCRR NIH HHS UL1 RR025005NHLBI NIH HHS T32 HL125239NICHD NIH HHS R21 HD072845NINDS NIH HHS K08 NS080984NINDS NIH HHS R01 NS060703NINDS NIH HHS R01 NS107417NINDS NIH HHS R21 NS095036
6 · The paper itself

Abstract

objectivesTo determine the effect of the duration of asphyxial arrest on the survival benefit previously seen with end-tidal CO2-guided chest compression delivery.

designPreclinical randomized controlled study.

settingUniversity animal research laboratory. SUBJECTS: Two-week-old swine.

interventionsAfter either 17 or 23 minutes of asphyxial arrest, animals were randomized to standard cardiopulmonary resuscitation or end-tidal CO2-guided chest compression delivery. Standard cardiopulmonary resuscitation was optimized by marker, monitor, and verbal feedback about compression rate, depth, and release. End-tidal CO2-guided delivery used adjustments to chest compression rate and depth to maximize end-tidal CO2 level without other feedback. Cardiopulmonary resuscitation for both groups proceeded from 10 minutes of basic life support to 10 minutes of advanced life support or return of spontaneous circulation. MEASUREMENTS AND MAIN

resultsAfter 17 minutes of asphyxial arrest, mean end-tidal CO2 during 10 minutes of cardiopulmonary resuscitation was 18 ± 9 torr in the standard group and 33 ± 15 torr in the end-tidal CO2 group (p = 0.004). The rate of return of spontaneous circulation was three of 14 (21%) in the standard group rate and nine of 14 (64%) in the end-tidal CO2 group (p = 0.05). After a 23-minute asphyxial arrest, neither end-tidal CO2 values (20 vs 26) nor return of spontaneous circulation rate (3/14 vs 1/14) differed between the standard and end-tidal CO2-guided groups.

conclusionsOur previously observed survival benefit of end-tidal CO2-guided chest compression delivery after 20 minutes of asphyxial arrest was confirmed after 17 minutes of asphyxial arrest. The poor survival after 23 minutes of asphyxia shows that the benefit of end-tidal CO2-guided chest compression delivery is limited by severe asphyxia duration.

Indexed as

Blood CirculationAnimalsAnimals, NewbornArterial PressureAsphyxiaBlood Gas AnalysisCapnographyCarbon DioxideCardiopulmonary ResuscitationDiastoleDisease Models, AnimalFeedbackMaleMonitoring, PhysiologicRandom AllocationSwineCarbon Dioxide

Identifiers

PMID31149967
PMCPMC6612600

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.