ArticleAmerican journal of physiology. Heart and circulatory physiology2019
Sympathetic neural responsiveness to sleep deprivation in older adults: sex differences.
Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality.GeroScience · 2025Pooled it
- Gender correlation between sleep duration and risk of coronary heart disease: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Evening binge alcohol disrupts cardiovagal tone and baroreflex function during polysomnographic sleep.Sleep · 2021Trial
- Morning sympathetic activity after evening binge alcohol consumption.American journal of physiology. Heart and circulatory physiology · 2021Trial
- Heart rate and vascular responses to spontaneous arousals following experimental sleep restriction.American journal of physiology. Heart and circulatory physiology · 2026Article
- Neuromodulation and Copper Chelation Reverse Sleep Fragmentation-Aggravated Myocardial Ischemia-Reperfusion Injury by Targeting NET-Induced Endothelial Cuproptosis.Research (Washington, D.C.) · 2026Article
- Sleep fragmentation exacerbates myocardial ischemia-reperfusion injury via hypothalamic paraventricular nucleus-resident OX1R-mediated sympathetic hyperactivity in adult mice.Annals of medicine · 2025Article
- Habitual sleep duration is associated with heightened muscle sympathetic nerve activation and blood pressure reactivity in response to the cold pressor test.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Article
- Actigraphy-based sleep and muscle sympathetic nerve activity in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes.Nature communications · 2024Article
- Sleep disturbance and sympathetic neural reactivity in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2024Article
- Aging and sympathetic transduction to blood pressure in humans: methodological and physiological considerations.American journal of physiology. Heart and circulatory physiology · 2024Article
- An Update on Sleep Duration, Obesity, and Mortality Risk in Women.Sleep medicine clinics · 2023Review
- Sleep efficiency and PTSD symptom severity predict microvascular endothelial function and arterial stiffness in young, trauma-exposed women.American journal of physiology. Heart and circulatory physiology · 2023Article
- Sex Differences in Neurovascular Control: Implications for Obstructive Sleep Apnea.International journal of molecular sciences · 2023Review
- The stress of losing sleep: Sex-specific neurobiological outcomes.Neurobiology of stress · 2023Article
- Blood pressure and muscle sympathetic nerve activity are associated with trait anxiety in humans.American journal of physiology. Heart and circulatory physiology · 2023Article
- The association between sleep deprivation and arterial pressure variations: a systematic literature review.Sleep medicine: X · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Our laboratory has previously reported that total sleep deprivation (TSD) modifies muscle sympathetic neural activity (MSNA) differently in young men and women. Because postmenopausal women are among the highest risk for hypertension, this study compares MSNA responses with TSD in older men and women. We hypothesized that TSD would alter MSNA in older adults, with greater sympathoexcitation in postmenopausal women. Twenty-seven participants (14 men and 13 women) between the ages of 55 and 75 yr were tested twice, once after 24-h TSD and once after normal sleep (randomized, crossover design). Our primary outcome measure of MSNA (microneurography) was successful across both conditions in 20 participants (10 men and 10 women). Secondary outcome measures included seated blood pressure, heart rate, and fasting plasma testosterone, estradiol, and progesterone. Age (60 ± 1 vs. 61 ± 2 yr) and BMI (27 ± 1 vs. 26 ± 1 kg/m
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.