ArticleScience advances2019
Early divergence of mutational processes in human fetal tissues.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.Nature reviews. Genetics · 2025Review
- An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying SFPQ-TFE3 driven translocation RCC.iScience · 2025Article
- Post-implantation analysis of genomic variations in the progeny from developing fetus to birth.Human genomics · 2024Article
- Chance, ignorance, and the paradoxes of cancer: Richard Peto on developing preventative strategies under uncertainty.European journal of epidemiology · 2023Article
- Stem cell mutations, associated cancer risk, and consequences for regenerative medicine.Cell stem cell · 2023Review
- Cancers make their own luck: theories of cancer origins.Nature reviews. Cancer · 2023Review
- The genome-wide mutational consequences of DNA hypomethylation.Scientific reports · 2023Article
- The origins and functional effects of postzygotic mutations throughout the human life span.Science (New York, N.Y.) · 2023Article
- Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue.Nature communications · 2022Article
- Game of clones: Battles in the field of carcinogenesis.Pharmacology & therapeutics · 2022Review
- Article
- Pathogenic postzygotic mosaicism in the tyrosine receptor kinase pathway: potential unidentified human disease hidden away in a few cells.The FEBS journal · 2021Review
- Article
- Clonal expansion in non-cancer tissues.Nature reviews. Cancer · 2021Review
- The Dynamics of Somatic Mutagenesis During Life in Humans.Frontiers in aging · 2021Review
- The Origin of B-cells: Human Fetal B Cell Development and Implications for the Pathogenesis of Childhood Acute Lymphoblastic Leukemia.Frontiers in immunology · 2021Review
- Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis.Scientific reports · 2020Article
- Germline mutation rates in young adults predict longevity and reproductive lifespan.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability. Here, we accurately quantified and characterized somatic mutation accumulation in fetal tissues by analyzing individual stem cells from human fetal liver and intestine. Fetal mutation rates were about fivefold higher than in tissue-matched adult stem cells. The mutational landscape of fetal intestinal stem cells resembled that of adult intestinal stem cells, while the mutation spectrum of fetal liver stem cells is distinct from stem cells of the fetal intestine and the adult liver. Our analyses indicate that variation in mutational mechanisms, including oxidative stress and spontaneous deamination of methylated cytosines, contributes to the observed divergence in mutation accumulation patterns and drives genetic mosaicism in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.