ArticleScience advances2019
Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- CSF Leukocytes in Intracranial Infections: Diagnostic, Mechanistic, and Therapeutic Insights for Neurocritical Care.Cellular and molecular neurobiology · 2026Review
- Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis.BMC medicine · 2026Article
- A probabilistic deep learning approach for choroid plexus segmentation in autism spectrum disorder.NPP - digital psychiatry and neuroscience · 2026Article
- Impact of acute stress exposure on genome-wide DNA methylation.Scientific reports · 2025Article
- Immune control of brain physiology.Nature reviews. Immunology · 2025Review
- Systems neuroimmunology: current bottlenecks, research priorities and future directions.Nature immunology · 2025Article
- Emerging role of adaptive immunity in diabetes-induced cognitive impairment: from the periphery to the brain.Metabolic brain disease · 2025Review
- Mapping the epigenomic landscape of post-traumatic stress disorder in human cortical neurons.medRxiv : the preprint server for health sciences · 2024Article
- Targeting the glucocorticoid receptor-CCR8 axis mediated bone marrow T cell sequestration enhances infiltration of anti-tumor T cells in intracranial cancers.Cellular & molecular immunology · 2024Article
- The telencephalon is a neuronal substrate for systemic inflammatory responses in teleosts via polyamine metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Brain regulatory T cells.Nature reviews. Immunology · 2024Review
- Frontiers and future perspectives of neuroimmunology.Fundamental research · 2024Review
- Inflammation in Posttraumatic Stress Disorder: Dysregulation or Recalibration?Current neuropharmacology · 2024Article
- Stress promotes the infiltration of peripheral immune cells to the brain.Brain, behavior, and immunity · 2023Article
- Blocking the IFN-gamma signal in the choroid plexus confers resistance to experimental autoimmune encephalomyelitis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Deconstructing the functional neuroanatomy of the choroid plexus: an ontogenetic perspective for studying neurodevelopmental and neuropsychiatric disorders.Molecular psychiatry · 2022Review
- Interleukin-4 receptor signaling modulates neuronal network activity.The Journal of experimental medicine · 2022Article
- Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence.Biomedicines · 2022Review
- Choroid plexus-selective inactivation of adenosine AJournal of neuroinflammation · 2022Article
- B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation.Brain, behavior, and immunity · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
The immune system supports brain plasticity and homeostasis, yet it is prone to changes following psychological stress. Thus, it remains unclear whether and how stress-induced immune alterations contribute to the development of mental pathologies. Here, we show that following severe stress in mice, leukocyte trafficking through the choroid plexus (CP), a compartment that mediates physiological immune-brain communication, is impaired. Blocking glucocorticoid receptor signaling, either systemically or locally through its genetic knockdown at the CP, facilitated the recruitment of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.