ArticleBiomedical optics express2019
Moments reconstruction and local dynamic range compression of high order superresolution optical fluctuation imaging.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- SPIFFI enables single-shot super-resolution and multidimensional imaging.Nature methods · 2026Article
- Molecular histopathology of matrix proteins through autofluorescence super-resolution microscopy.Scientific reports · 2024Article
- High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation.Nature methods · 2023Article
- Fluorescence fluctuation-based super-resolution microscopy: Basic concepts for an easy start.Journal of microscopy · 2022Review
- Article
- Rapid ensemble measurement of protein diffusion and probe blinking dynamics in cells.Biophysical reports · 2021Article
- Cusp-artifacts in high order superresolution optical fluctuation imaging.Biomedical optics express · 2020Article
- Moments reconstruction and local dynamic range compression of high order superresolution optical fluctuation imaging.Biomedical optics express · 2019Article
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Authors and funding
5 authors.
Funding
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Abstract
Super-resolution optical fluctuation imaging (SOFI) offers a simple and affordable alternative to other super-resolution (SR) imaging techniques. The theoretical resolution enhancement of SOFI scales linearly with the order of cumulants, while the imaging conditions exhibit less photo-toxicity to the living samples as compared to other SR methods. High order SOFI could, therefore, be a method of choice for dynamic live cell imaging. However, due to the cusp-artifacts and dynamic range expansion of pixel intensities, this promise has not been materialized as of yet. Here we investigated and compared high order moments vs. high order cumulant SOFI reconstructions. We demonstrate that even-order moments reconstructions are intrinsically free of cusp artifacts, allowing for a subsequent deconvolution operation to be performed, hence enhancing the resolution even further. High order moments reconstruction performance was examined for various (simulated) conditions and applied to (experimental) imaging of QD labeled microtubules in fixed cells, and actin stress fiber dynamics in live cells.
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Registered trials
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